Pathophysiological role of prostaglandin E synthases in liver diseases
| Autor: | Gao Hang, Wan Zhikang, Jie Cai, Ying Sun, Delong Xu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Physiology medicine.medical_treatment 030204 cardiovascular system & hematology Biochemistry 03 medical and health sciences chemistry.chemical_compound Liver disease 0302 clinical medicine medicine Phosphofructokinase 2 Prostaglandin E2 Prostaglandin-E Synthases Pharmacology chemistry.chemical_classification biology Cell Biology medicine.disease 030104 developmental biology Enzyme chemistry biology.protein lipids (amino acids peptides and proteins) Cyclooxygenase Prostaglandin H2 medicine.drug Prostaglandin E |
| Zdroj: | Prostaglandinsother lipid mediators. 154 |
| ISSN: | 1098-8823 |
| Popis: | Prostaglandin E synthases (PGESs) convert cyclooxygenase (COX)-derived prostaglandin H2 (PGH2) into prostaglandin E2 (PGE2) and comprise at least three types of structurally and biologically distinct enzymes. Two of these, namely microsomal prostaglandin E synthase-1 (mPGES-1) and mPGES-2, are membrane-bound enzymes. mPGES-1 is an inflammation-inducible enzyme that converts PGH2 into PGE2. mPGES-2 is a bifunctional enzyme that generally forms a complex with haem in the presence of glutathione. This enzyme can metabolise PGH2 into malondialdehyde and can produce PGE2 after its separation from haem. In this review, we discuss the role of PGESs, particularly mPGES-1 and mPGES-2, in the pathogenesis of liver diseases. A better understanding of the roles of PGESs in liver disease may aid in the development of treatments for patients with liver diseases. |
| Databáze: | OpenAIRE |
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