Treatment satisfaction in renal transplant patients taking tacrolimus once daily
| Autor: | Gerben A.J. van Boekel, Luuk B. Hilbrands, Chantal H.H. Kerkhofs |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Cross-sectional study Auto-immunity transplantation and immunotherapy [N4i 4] Organ transplantation Drug Administration Schedule Tacrolimus Internal medicine Surveys and Questionnaires medicine Ingestion Humans Pharmacology (medical) Prospective Studies Prospective cohort study Kidney transplantation Pharmacology business.industry Effective primary care and public health [NCEBP 7] Middle Aged medicine.disease Kidney Transplantation Surgery Transplantation Regimen Cross-Sectional Studies Treatment Outcome Patient Compliance Drug Therapy Combination Female Immune Regulation Auto-immunity transplantation and immunotherapy [NCMLS 2] business Immunosuppressive Agents |
| Zdroj: | Clinical Therapeutics, 35, 11, pp. 1821-1829 e1 Clinical Therapeutics, 35, 1821-1829 e1 |
| ISSN: | 0149-2918 |
| Popis: | Item does not contain fulltext BACKGROUND: Adherence to immunosuppressive therapy, which is important to prevent rejection after organ transplantation, is influenced by satisfaction of patients with their medication regimen. OBJECTIVE: We investigated the effect of introducing a simplified medication regimen for renal transplant patients on treatment satisfaction, in particular, convenience. METHODS: In a prospective cohort study, treatment was switched from tacrolimus twice daily to tacrolimus once daily with a simultaneous change to a once-daily formulation of other drugs when applicable. Treatment satisfaction was measured in 75 participants with the validated Treatment Satisfaction Questionnaire for Medication version II. RESULTS: The treatment convenience score increased from a mean (SD) of 66.0 (14.5) to 78.5 (14.5) (P < 0.001). The mean (SD) daily number of medication ingestion time points diminished from 2.4 (0.7) to 1.6 (0.7) (P < 0.001), and the mean (SD) daily number of tablets decreased from 12.4 (3.3) to 9.1 (2.6) (P < 0.001). The self-reported adherence to the medication regimen increased from 79.7% to 94.6% (P < 0.001). CONCLUSIONS: The introduction of a simplified medication regimen enabled by the use of a once-daily formulation of tacrolimus increases treatment convenience after renal transplantation. This regimen had a beneficial effect on self-reported adherence. |
| Databáze: | OpenAIRE |
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