Anti-inflammatory and sedative activities of Peperomia galioides
| Autor: | Isabel Wilches, Francesc Jiménez-Altayó, Yvan Vander Heyden, Elisabet Vila, Vladimiro Tobar, M. Victòria Clos, Priscila Jiménez-Castillo, Eugenia Peñaherrera, Nancy Cuzco, Lourdes Jerves-Andrade, Fabián León-Tamariz |
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| Přispěvatelé: | Department of Analytical Chemistry, Applied Chemometrics and Molecular Modelling, Pharmaceutical and Pharmacological Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Peperomia galioides
biology Lipopolysaccharide 010405 organic chemistry medicine.drug_class Chemistry Organic Chemistry Inflammation Plant Science Pharmacology biology.organism_classification 01 natural sciences Biochemistry Croton Anti-inflammatory 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound In vivo Myeloperoxidase Sedative biology.protein medicine medicine.symptom |
| Popis: | Aerial parts (leaves, flowers, stem) of Peperomia galioides extract administered to mice, was used to confirm its anti-inflammatory and sedative folk uses. The anti-inflammatory activity was assessed by croton oil-induced ear oedema and myeloperoxidase (acute inflammation); cotton pellet-induced granuloma (sub-acute inflammation) and Escherichia coli Lipopolysaccharide (LPS) induced inflammation (cellular mediators). The sedative activity was studied by the pentobarbital-induced sleeping time test. Single doses (300 and 600 mg/kg; i.p.) of the extract reduced croton oil-induced ear oedema and myeloperoxidase activity. Six days administration of the extract (300 mg/kg, i.p.) to mice implanted with cotton pellets diminished granuloma formation. LPS (20 mg/kg, i.p.) enhanced plasma nitrites and TNF-α levels that were inhibited by the extract. The duration but not the onset of sleeping time was enhanced by 300 and 600 mg/kg of the extract. Our results show that P. galioides has anti-inflammatory and sedative activities in mice, which validates its traditional use. |
| Databáze: | OpenAIRE |
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