Prognostic impact of lung adenocarcinoma second predominant pattern from a large European database
| Autor: | Andrea Viti, Marco Lucchi, Maria Rodriguez Perez, Diana Bacchin, Filippo Lococo, Stefano Margaritora, Alberto Terzi, Luigi Ventura, Letizia Gnetti, Enrico Ruffini, Guido Rindi, Salvatore Bellafiore, Giulia Querzoli, Massimiliano Paci, Francesca Franzi, Maria Cattoni, Federico Femia, Dania Nachira, Pietro Bertoglio, Fabrizio Minervini, Luca Ampollini, Francesco Guerrera, Giuseppe Bogina, Andrea Imperatori, Peter Kestenholz, Vittorio Aprile |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Lung Neoplasms Databases Factual medicine.medical_treatment Papillary Acinar Cell Gastroenterology 0302 clinical medicine Settore MED/21 - CHIRURGIA TORACICA Lung cancer surgery General Medicine Prognosis Europe Survival Rate Adenocarcinoma Papillary medicine.anatomical_structure lung adenocarcinoma lung cancer biology lung cancer surgery non-small-cell lung cancer Adenocarcinoma of Lung Aged Carcinoma Acinar Cell Female Follow-Up Studies Humans Neoplasm Recurrence Local Retrospective Studies Oncology Local 030220 oncology & carcinogenesis Adenocarcinoma 030211 gastroenterology & hepatology medicine.medical_specialty 03 medical and health sciences Databases Internal medicine medicine Pathological Factual Cancer staging Lung business.industry Carcinoma Retrospective cohort study Histology medicine.disease Neoplasm Recurrence Surgery Lymphadenectomy business |
| Popis: | Background and objectives Adenocarcinoma patterns could be grouped based on clinical behaviors: low- (lepidic), intermediate- (papillary or acinar), and high-grade (micropapillary and solid). We analyzed the impact of the second predominant pattern (SPP) on disease-free survival (DFS). Methods We retrospectively collected data of surgically resected stage I and II adenocarcinoma. Selection criteria anatomical resection with lymphadenectomy and pathological N0. Pure adenocarcinomas and mucinous subtypes were excluded. Recurrence rate and factors affecting DFS were analyzed according to the SPP focusing on intermediate-grade predominant pattern adenocarcinomas. Results Among 270 patients, 55% were male. The mean age was 68.3 years. SPP pattern appeared as follows: lepidic 43.0%, papillary 23.0%, solid 14.4%, acinar 11.9%, and micropapillary 7.8%. The recurrence rate was 21.5% and 5-year DFS was 71.1%. No difference in DFS was found according to SPP (p = .522). In patients with high-grade SPP, the percentage of SPP, age, and tumor size significantly influenced DFS (p = .016). In patients with lepidic SPP, size, male gender, and lymph-node sampling (p = .005; p = .014; p = .038, respectively) significantly influenced DFS. Conclusions The impact of SPP on DFS is not homogeneous in a subset of patients with the intermediate-grade predominant patterns. The influence of high-grade SPP on DFS is related to its proportion in the tumor. |
| Databáze: | OpenAIRE |
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