Genomic Regions Associated with Fusarium Wilt Resistance in Flax
| Autor: | Tatyana Rozhmina, Mikhail Bankin, Anastasia Samsonova, Maria Samsonova, Alexander Kanapin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Fusarium
Genotype QH301-705.5 flax Quantitative Trait Loci Single-nucleotide polymorphism Biology Quantitative trait locus Genes Plant Polymorphism Single Nucleotide Catalysis Article immune response Chromosomes Plant Russia Inorganic Chemistry resistance Fusarium oxysporum GWAS fusarium wilt Cultivar Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy Alleles Disease Resistance Plant Diseases Genetics Strain (biology) Organic Chemistry fungi food and beverages General Medicine biology.organism_classification disease severity index Fusarium wilt Computer Science Applications Chemistry Plant Breeding Phenotype Genome-Wide Association Study |
| Zdroj: | International Journal of Molecular Sciences Volume 22 Issue 22 International Journal of Molecular Sciences, Vol 22, Iss 12383, p 12383 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Modern flax cultivars are susceptible to many diseases arguably, the most economically damaging of these is the Fusarium wilt fungal disease. Over the past decades international flax breeding initiatives resulted in the development of resistant cultivars. However, much remains to be learned about the mechanisms of resistance to Fusarium infection in flax. As a first step to uncover the genetic factors associated with resistance to Fusarium wilt disease, we performed a genome-wide association study (GWAS) using 297 accessions from the collection of the Federal Research Centre of the Bast Fiber Crops, Torzhok, Russia. These genotypes were infected with a highly pathogenic Fusarium oxysporum f.sp. lini MI39 strain the wilt symptoms were documented in the course of three successive years. Six different single-locus models implemented in GAPIT3 R package were applied to a selected subset of 72,526 SNPs. A total of 15 QTNs (Quantitative Trait Nucleotides) were detected during at least two years of observation, while eight QTNs were found during all three years of the experiment. Of these, ten QTNs occupied a region of 640 Kb at the start of chromosome 1, while the remaining QTNs mapped to chromosomes 8, 11 and 13. All stable QTNs demonstrate a statistically significant allelic effect across 3 years of the experiment. Importantly, several QTNs spanned regions that harbored genes involved in the pathogen recognition and plant immunity response, including the KIP1-like protein (Lus10025717) and NBS-LRR protein (Lus10025852). Our results provide novel insights into the genetic architecture of flax resistance to Fusarium wilt and pinpoint potential candidate genes for further in-depth studies. |
| Databáze: | OpenAIRE |
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