Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts
| Autor: | Sandra Rugonyi, Robert P. Cary, Xin Yin, Kent L. Thornburg, Ruikang K. Wang, Aaron Troyer, Aiping Liu, Andrew Nickerson |
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| Rok vydání: | 2011 |
| Předmět: |
Embryonic heart
Mechanical Engineering Morphogenesis Hemodynamics Blood flow Wall shear Biology Embryonic stem cell Article Computer Science Applications Cell biology Modeling and Simulation cardiovascular system Shear stress General Materials Science Outflow circulatory and respiratory physiology Civil and Structural Engineering |
| Zdroj: | Computers & Structures. 89:855-867 |
| ISSN: | 0045-7949 |
| DOI: | 10.1016/j.compstruc.2011.03.003 |
| Popis: | Wall shear stresses (WSS) exerted by blood flow on cardiac tissues modulate growth and development of the heart. To study the role of hemodynamic conditions on cardiac morphogenesis, here, we present a methodology that combines imaging and finite element modeling to quantify the in vivo blood flow dynamics and WSS in the cardiac outflow tract (OFT) of early chicken embryos (day 3 out of 21-day incubation period). We found a distinct blood flow field and heterogeneous distribution of WSS in the chicken embryonic heart OFT, which have physiological implications for OFT morphogenesis. |
| Databáze: | OpenAIRE |
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