Setosphlides A–D, New Isocoumarin Derivatives from the Entomogenous Fungus Setosphaeria rostrate LGWB-10
| Autor: | Fei Cao, Fengli Chen, Xiaoxia Wang, Chunqing Li, Du-Qiang Luo, Wenbin Gao |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Isocoumarin biology Chemistry Stereochemistry Chemical shift Entomogenous fungus Organic Chemistry Absolute configuration Plant Science Fungus Carbon-13 NMR Toxicology biology.organism_classification Biochemistry Setosphaeria rostrate Analytical Chemistry Human tumor chemistry.chemical_compound Setosphaeria Original Article Epimer Food Science |
| Zdroj: | Natural Products and Bioprospecting |
| ISSN: | 2192-2209 2192-2195 |
| Popis: | Abstract Investigation of the entomogenous fungus Setosphaeria rostrate LGWB-10 from Harmonia axyridis led to the isolation of four new isocoumarin derivatives, setosphlides A–D (1–4), and four known analogues (5–8). Their planar structures and the relative configurations were elucidated by comprehensive spectroscopic methods. The absolute configurations of isocoumarin nucleus for 1–4 were elucidated by their ECD spectra. The C-10 relative configurations for the pair of C-10 epimers (1 and 2) were established by comparing the magnitude of the computed 13C NMR chemical shifts (Δδcalcd.) with the experimental 13C NMR values (Δδexp.) for the epimers. All of the isolated compounds (1–8) were evaluated for their cytotoxicities against four human tumor cell lines MCF-7, MGC-803, HeLa, and Huh-7. Graphic Abstract |
| Databáze: | OpenAIRE |
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