Glucose Measurement of Intensive Care Unit Patient Plasma Samples Using a Fixed-Wavelength Mid-Infrared Spectroscopy System

Autor: Kelly Bochicchio, James S. Krinsley, Grant V. Bochicchio, Christopher Calentine
Rok vydání: 2012
Předmět:
Adult
Blood Glucose
Male
medicine.medical_specialty
Adolescent
Critical Illness
Endocrinology
Diabetes and Metabolism
Biomedical Engineering
Bioengineering
law.invention
Young Adult
Predictive Value of Tests
law
Spectroscopy
Fourier Transform Infrared
Internal Medicine
medicine
Humans
Prospective Studies
Intensive care medicine
Prospective cohort study
APACHE
Aged
Monitoring
Physiologic
Glycemic
Metoprolol
Aged
80 and over
business.industry
Glucose Measurement
Reproducibility of Results
Signal Processing
Computer-Assisted
Middle Aged
Reference Standards
Intensive care unit
Connecticut
Intensive Care Units
Standard error
Predictive value of tests
Baltimore
Emergency medicine
Linear Models
Feasibility Studies
Original Article
Female
Volume expander
business
Algorithms
Biomarkers
medicine.drug
Zdroj: Journal of Diabetes Science and Technology. 6:294-301
ISSN: 1932-2968
DOI: 10.1177/193229681200600212
Popis: Objective: Glycemic control is a rapidly developing field in intensive care medicine with the aim of reducing mortality, morbidity, and cost. Current intensive care unit (ICU) glucose measurement technologies are susceptible to interference from medications, volume expanders, and other substances present in critically ill patients. We hypothesized that a fixed-wavelength mid-infrared (mid-IR) spectroscopy system would be accurate for measuring glucose levels of ICU patients. Research Design and Methods: This is a prospective investigation of plasma samples from two different institutions treating a heterogeneous population of ICU patients. The first 292 samples were collected from 86 patients admitted to Stamford Hospital, and the next 352 samples were collected from 75 patients from three ICUs at the University of Maryland. Plasma samples were measured on a Fourier-transform infrared or a proprietary spectrometer, with a glucose prediction algorithm to correct for spectral interference, which were compared with reference measurements taken using a YSI 2300 glucose analyzer. Results: Glucose values ranged from 24 to 343 mg/dl. Numerous medications and injury/disease states were observed in the patient populations, with metoprolol, fentanyl, and multiple organ failure the most prevalent. Despite these interferents, there was a high correlation (r ≥ 0.94) and low standard error (≤12.8 mg/dl) between the predicted glucose values and those of the YSI 2300 STAT Plus reference instrument in the three studies. A total of 95.1% of the 644 values in the three studies met International Organization for Standardization 15197 criteria. Conclusion: These results suggest that a fixed-wavelength mid-IR spectrometer can measure glucose accurately in the plasma of ICU patients.
Databáze: OpenAIRE
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