TGF-β activates ERK5 in human renal epithelial cells
| Autor: | Riad Abou Zahr, Ioana Niculescu-Duvaz, Mark E. C. Dockrell, James A. Browne, Alex Pearson, Deborah L. Baines |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Pyridines
MAPK7 Receptor Transforming Growth Factor-beta Type I Biophysics MADS Domain Proteins Protein Serine-Threonine Kinases Mitogen-activated protein kinase kinase Biology Kidney p38 Mitogen-Activated Protein Kinases Biochemistry MAP2K7 Transforming Growth Factor beta Cell Line Tumor Humans ASK1 Protein Kinase Inhibitors Molecular Biology Mitogen-Activated Protein Kinase 7 MAPK14 MAP kinase kinase kinase MEF2 Transcription Factors Cyclin-dependent kinase 2 Imidazoles Epithelial Cells Cell Biology Transforming growth factor beta Cell biology Myogenic Regulatory Factors biology.protein Receptors Transforming Growth Factor beta |
| Zdroj: | Biochemical and Biophysical Research Communications. 373:440-444 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2008.06.058 |
| Popis: | The role of the MAP kinase, extracellular signal-regulated kinase 5 (ERK5) remains unknown, however it is involved in cell differentiation and survival as highlighted by the embryonic lethality of the ERK5 knockout. ERK5 can be activated by growth factors and other extracellular signals. TGF-beta, a powerful controller of epithelial cell phenotype, is known to activate the MAP kinase, ERK1/2 however its effect on ERK5 remains unknown. This study demonstrates, fort the first time, ERK5 activation by TGF-beta, observed in both transformed and primary adult human PTEC; activation required ALK-5 receptor activity. In addition this work demonstrates expression of myocyte enhancer factor-2 (MEF2C) by PTEC and that TGF-beta increased the association of MEK5 with phospho-ERK5 and MEF2C. ERK5 activation by either TGF-beta or epidermal growth factor (EGF) was also inhibited by the p38 MAP kinase inhibitor, SB-202190. |
| Databáze: | OpenAIRE |
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