Effect of anti-epileptic drugs on first trimester screening test results
| Autor: | M. Sinan Beksaç, Erdem Fadiloglu, Atakan Tanacan, Oytun Portakal, Canan Unal |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Drug
Adult medicine.medical_specialty media_common.quotation_subject Disease Lamotrigine lcsh:Gynecology and obstetrics Statistics Nonparametric First trimester screening test Epilepsy Pregnancy Internal medicine Valproic acid medicine Humans Pregnancy-Associated Plasma Protein-A Chorionic Gonadotropin beta Subunit Human lcsh:RG1-991 media_common Retrospective Studies Valproic Acid business.industry Obstetrics and Gynecology Carbamazepine medicine.disease Pregnancy Complications Pregnancy Trimester First Case-Control Studies Mann–Whitney U test Anticonvulsants Female business Maternal Serum Screening Tests medicine.drug |
| Zdroj: | Taiwanese Journal of Obstetrics & Gynecology, Vol 59, Iss 6, Pp 835-837 (2020) |
| ISSN: | 1875-6263 |
| Popis: | Objective: To evaluate first trimester screening test parameters in epileptic patients using anti-epileptic drugs. Materials and methods: We retrospectively evaluated first trimester screening test results of 23 epileptic pregnant women using anti-epileptic drugs with a control group consisting of 92 healthy pregnancies. The anti-epileptic drugs used in this study were carbamazepine, levatiracetam, valproic acid and lamotrigine. Single drug or multi-drug regimens were used according to the clinical conditions. Patients with any known chronic or acute disease and drug usage were excluded from the study. Comparisons were performed via Mann–Whitney U test. Results: First trimester screening test biochemical markers were compared and maternal serum PAPP-A MoM values were found to be similar in study and control groups while β-hCG MoM values were significantly higher in pregnancies using epileptic drugs (p: 0,737 and p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|