The perinatal and postnatal toxicity of d-methylphenidate and d,l-methylphenidate in rats
| Autor: | Vikram Khetani, Alan M. Hoberman, Steve D. Thomas, Steve K. Teo, David I. Stirling, Mildred S. Christian |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Dexmethylphenidate Toxicology Rats Sprague-Dawley Embryonic and Fetal Development Pregnancy Internal medicine Lactation Toxicity Tests Animals Medicine Attention deficit hyperactivity disorder Dose-Response Relationship Drug business.industry Methylphenidate Reproduction Body Weight Pupil Stereoisomerism medicine.disease Teratology Rats Endocrinology medicine.anatomical_structure Animals Newborn Toxicity Gestation Central Nervous System Stimulants Female Vocalization Animal medicine.symptom business Weight gain medicine.drug |
| Zdroj: | Reproductive Toxicology. 16:353-366 |
| ISSN: | 0890-6238 |
| DOI: | 10.1016/s0890-6238(02)00044-8 |
| Popis: | d -Methylphenidate is an enantiomer of d , l -methylphenidate and was developed as an improved treatment for attention deficit hyperactivity disorder (ADHD) in children. The current study was performed to assess the potential perinatal and postnatal toxicity of both compounds in rats. About 125 presumed pregnant rats were assigned to five dose groups of 25 each. They were dosed with 2, 6, and 20 mg/kg/day d -methylphenidate and 40 mg/kg/day d , l -methylphenidate from gestation Day 7 to lactation Day 20. F1 generation rats were rebred to produce F2 fetuses. Various perinatal and postnatal measurements were made for the F0 and F1 rats. Among the significant findings were a reduction in maternal body weight gain for 20 mg/kg/day d- methylphenidate and d , l -methylphenidate and increased incidences of dilated pupil and vocalization for d , l -methylphenidate during the gestation period. Neither compound produced any other significant adverse findings in F0 and F1 generation rats at doses that were at least 25 times the maximum daily human therapeutic dose. |
| Databáze: | OpenAIRE |
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