Efficacy of afoxolaner (NexGard®) on the treatment of myiasis caused by the New World screwworm fly Cochliomyia hominivorax (Diptera: Calliphoridae) in naturally infested dogs
| Autor: | Ingrid Menz, André Antonio Cutolo, Fabiano O. Silva, Nadège Perier, Patricia Jacqueline Thyssen, Frederic Beugnet |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Veterinary medicine animal structures 030231 tropical medicine Naphthalenes medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound Myiasis 0302 clinical medicine Calliphoridae Dogs parasitic diseases Infestation medicine Animals Dog Diseases Ectoparasiticide Larva General Veterinary biology Maggot Diptera fungi Isoxazoles 030108 mycology & parasitology biology.organism_classification medicine.disease chemistry Instar Parasitology Cochliomyia hominivorax |
| Zdroj: | Veterinary parasitology, regional studies and reports. 24 |
| ISSN: | 2405-9390 |
| Popis: | New World screwworm (NWS) myiasis is an infestation by Cochliomyia hominivorax larvae that consume the living tissue of warm-blooded animals, including humans. Domestic dogs are among the potential hosts of these flies that lay their eggs on the edges of wounds. NWS myiasis cases can be fatal if untreated. Treatment with parasiticides must be fast-acting, long-lasting and show 100% efficacy, since open wounds can be reinfested. Afoxolaner is a molecule from the isoxazoline family with proven ectoparasiticide action against fleas, ticks and mites in dogs. Fourteen healthy client-owned dogs, naturally infested by C. hominivorax larvae, were treated with afoxolaner (NexGard®) as per label recommendations, providing at least the minimum dosage of 2.5 mg/kg. Maggot infestations were classified as light (fewer than 10 larvae), mild (from 10 to 20 larvae) or severe (more than 20 larvae), according to the number of larvae found in the wound and/or collected from the ground after treatment. Twenty-four hours post-treatment, infested lesions were carefully inspected and collected larvae were counted and classified as live or dead. All maggots were identified as second and third instar larvae of C. hominivorax and were found dead within 24 h after treatment, demonstrating 100% larvicidal efficacy against C. hominivorax. |
| Databáze: | OpenAIRE |
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