28 K cholecalcin (CaBP) levels in abnormal cerebella: studies on mutant mice and harmaline- and 3-acetylpyridine-treated rats
| Autor: | M. Thomasset, Jean Mariani, C.O. Parkes |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Cerebellum
medicine.medical_specialty Pyridines Purkinje cell Mutant Population Biology Harmaline chemistry.chemical_compound Mice Mice Neurologic Mutants Purkinje Cells Reeler Alkaloids S100 Calcium Binding Protein G Internal medicine medicine Animals education Molecular Biology education.field_of_study Kidney Mice Inbred BALB C Mice Inbred C3H General Neuroscience Calcium-Binding Proteins Vitamin D-dependent calcium-binding protein Mice Inbred C57BL medicine.anatomical_structure Endocrinology chemistry Mice Inbred CBA Hybridization Genetic Neurology (clinical) Developmental Biology |
| Zdroj: | Brain research. 339(2) |
| ISSN: | 0006-8993 |
| Popis: | The cerebellar Purkinje cells of both birds and mammals contain a specific calcium-binding protein, 28 K cholecalcin (CaBP). This is the same protein as the vitamin D-dependent kidney CaBP, but its Purkinje cell level is apparently vitamin D independent. The cerebellar CaBP contents of 3-acetylpyridine- and harmaline-treated rats and 5 mutant mouse strains (Purkinje cell degeneration, reeler, weaver, staggerer and nervous) were measured using a specific radioimmunoassay. The results indicate that the level of cerebellar CaBP is not dependent on the physiological state of the Purkinje cells but is an intrinsic measure of the size of the Purkinje cell population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|