Can We Prevent Sudden Unexpected Death in Epilepsy (SUDEP)?
| Autor: | Himani Bhasin, Suvasini Sharma, Rajesh RamachandranNair |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Epilepsy business.industry OPIATE ANTAGONISTS Cardiorespiratory fitness General Medicine Airway obstruction medicine.disease Unexpected death Distress Death Sudden Neurology Risk Factors Seizures Heart rate monitoring medicine Humans In patient Neurology (clinical) Sudden Unexpected Death in Epilepsy Intensive care medicine business Monitoring Physiologic |
| Zdroj: | The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. 48(4) |
| ISSN: | 0317-1671 |
| Popis: | Sudden unexpected death in epilepsy (SUDEP) remains an important cause of epilepsy-related mortality, especially in patients with refractory epilepsy. The exact cause is not known, but postictal cardiac, respiratory, and brainstem dysfunctions are implicated. SUDEP prevention remains a big challenge. Except for low-quality evidence of preventive effect of nocturnal supervision for SUDEP, no other evidence-based preventive modality is available. Other potential preventive strategies for SUDEP include reducing the occurrence of generalized tonic–clonic seizures using seizure detection devices, detecting cardiorespiratory distress through respiratory and heart rate monitoring devices, preventing airway obstruction (safety pillows), and reducing central hypoventilation using selective serotonin reuptake inhibitors and adenosine and opiate antagonists. However, none of the above-mentioned modalities has been proven to prevent SUDEP. The present review intends to provide insight into the available SUDEP prevention modalities. |
| Databáze: | OpenAIRE |
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