Anti-Toxoplasma activity of vegetal extracts used in West African traditional medicine
| Autor: | M. Mallie, D. Kone-Bamba, Françoise Benoit-Vical, M. Santillana-Hayat, F. Derouin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Veterinary (miscellaneous)
Plasmodium falciparum Drug Evaluation Preclinical Toxoplasma gondii Enzyme-Linked Immunosorbent Assay Decoction Pharmacognosy lcsh:Infectious and parasitic diseases medicinal plant parasitic diseases Combretum micranthum Animals lcsh:RC109-216 ethnopharmacology Medicinal plants Medicine African Traditional Sida acuta biology Traditional medicine Plant Extracts Verbenaceae Ximenia americana in vitro biology.organism_classification Infectious Diseases Insect Science Animal Science and Zoology Parasitology Ivory Coast Toxoplasma |
| Zdroj: | Parasite, Vol 7, Iss 1, Pp 3-7 (2000) |
| ISSN: | 1776-1042 |
| Popis: | Both Toxoplasma gondii and Plasmodium are Apicomplexan protozoa that share common metabolic pathways and potential drug targets. The objective of this study was to examine the anti- Toxoplasma activity of nine West African plants with known activity against P. falciparum . The extracts were obtained from parts of plant commonly used, by most traditional healers, in the form of infusion or as water decoction. The in vitro activity of plant extracts on T. gondii was assessed on MRC5 tissue cultures and was quantified by enzyme-linked immunoassay. Aqueous extracts from Vernonia colorata were found to be inhibitory for Toxoplasma growth at concentrations > 10 mg/L, with an IC50 of 16.3 mg/L. A ten-fold gain in activity was obtained when organic solvents such as dichloromethane, acetone or ethanol were used to extract V. colorata's active principles. These extracts were inhibitory at concentrations as low as 1 mg/L, with IC50 of 1.7, 2.6 and 2.9 mg/L for dichloromethane, acetone and ethanol extracts respectively. These results indicate a promising source of new anti-Toxoplasma drugs from V. colorata and African medicinal plants. |
| Databáze: | OpenAIRE |
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