Uveal metastasis: Clinical features and survival outcome of 2214 tumors in 1111 patients based on primary tumor origin
| Autor: | Jerry A. Shields, Alex J Altman, Alexander Graf, Eileen L. Mayro, Kunal Malik, R Joel Welch, Sean P. Considine, Mark P. McGarrey, Jennifer H Newman, Meredith A Spencer, Evan B. Selzer, Luis A. Acaba-Berrocal, Austen N. Knapp, Alexandru B Constantinescu, Carol L. Shields |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Uveal Neoplasms medicine.medical_specialty Adolescent Iris Diagnostic Techniques Ophthalmological Gastroenterology uvea Metastasis Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine metastasis Humans Neoplasm Metastasis Child Aged Neoplasm Staging Retrospective Studies Aged 80 and over Lung Choroid business.industry ciliary body Cancer General Medicine Middle Aged Pennsylvania Uvea Prognosis medicine.disease eye Primary tumor Survival Rate Ophthalmology medicine.anatomical_structure 030220 oncology & carcinogenesis Cutaneous melanoma 030221 ophthalmology & optometry Original Article Female Pancreas business |
| Zdroj: | Middle East African Journal of Ophthalmology |
| ISSN: | 0974-9233 |
| DOI: | 10.4103/meajo.meajo_6_18 |
| Popis: | PURPOSE: The purpose of this study is to evaluate patients with uveal metastasis based on primary tumor site. METHODS: Retrospective analysis from Wills Eye Hospital, Philadelphia, PA, USA, for uveal metastasis clinical features and outcomes based on the primary tumor site. RESULTS: There were 2214 uveal metastases diagnosed in 1111 consecutive patients. The demographics included mean age of 60 years (median 61 years), Caucasian race (88%), and female gender (64%). The tumor was unilateral (82%) and primary site was established before uveal metastasis (67%). The primary tumor originated in the breast (37%), lung (26%), kidney (4%), gastrointestinal (GI) tract (4%), cutaneous melanoma (2%), lung carcinoid (2%), prostate (2%), thyroid (1%), pancreas (1%), other sites (3%), and unknown (16%). Comparative analysis of the 5 most common primary sites (breast, lung, kidney, GI tract, and cutaneous melanoma), revealed metastasis at mean age (57, 62, 66, 61, 59 years), as unilateral tumor (74%, 86%, 85%, 93%, 85%), with mean number of metastasis/eye (1.9, 1.7, 1.0, 1.1, 2.0), and in females (99%, 46%, 26%, 25%, 30%). Choroidal metastases measured mean base (9.3, 10.2, 9.1, 11.0, 7.3 mm), mean thickness (2.4, 3.6, 4.4, 4.0, 2.9 mm), and demonstrated predominant color yellow (94%, 91%, 56%, 97%, 36%). Of the 769 patients with documented follow-up, mean patient survival was poor (22.2, 11.5, 8.6, 12.4, 11.4 months) and Kaplan–Meier analysis revealed 3-year survival (33%, 19%, 0%, 14%, 21%) and 5-year survival (24%, 13%, 0%, 14%, 21%). The worst survival was found in patients with pancreatic metastasis (mean 4.2 months) and best survival with lung carcinoid (92% at 5 years). CONCLUSION: In a tertiary referral service, uveal metastasis originates from cancer in the breast, lung, kidney, GI tract, cutaneous melanoma, or others. Overall prognosis is poor with 5-year survival at 23% and worst survival with pancreatic metastasis whereas best survival with lung carcinoid metastasis. |
| Databáze: | OpenAIRE |
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