Cholesterolosis: physical-chemical characteristics of human and diet-induced canine lesions
| Autor: | P. Tang, R.T. Holzbach, M. Marsh |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Pathology medicine.medical_specialty Clinical Biochemistry Gallbladder disease Autopsy Gallbladder Diseases Biology Fatty Acids Nonesterified Pathology and Forensic Medicine Lesion Cholesterol Dietary Dogs medicine Animals Bile Humans Clinical significance Lipid localization Molecular Biology Triglycerides Lamina propria Gallbladder Fatty streak Anatomy medicine.disease Disease Models Animal medicine.anatomical_structure Cholesterol Female Cholesterol Esters medicine.symptom |
| Zdroj: | Experimental and molecular pathology. 27(3) |
| ISSN: | 0014-4800 |
| Popis: | The present work describes an experimental model of diet-induced canine cholesterolosis and the first analysis of the tissue lipids of both canine and human lesions. Human gallbladder cholesterolosis represents a lipid infiltrative process observed at cholecystectomy or at autopsy. There is a spectrum between the type and extent of the lesion and its clinical significance. In the polypoid form, which accounts for less than one-third of the lesions, a clinical picture closely resembling that of biliary tract disease can result; however, the preponderance of lesions are planar and asymptomatic. We recently discovered that induction of a reproducible canine lesion with similarities to the human planar form of cholesterolosis occurred by prolonged feeding of a cholesterol-cholic acid-containing diet in a total of 12 dogs. In order to compare and contrast these induced canine lesions with those found in humans, a total of 17 human gallbladder cholesterolosis samples were collected, and identical physico-chemical studies were performed where sufficient sample size from either source permitted. The main findings of the present work are: First, dietary induction of a reproducible canine cholesterolosis lesion has been demonstrated; gross and histopathological similarities to those in man are seen, with the most notable difference being that the canine lesion is entirely epithelial, whereas the human lesion is localized to the immediately adjacent lamina propria; second, the spontaneous lesions have physical-chemical similarities, namely, similarity of associated lipid classes and the presence physically of a two-phase system with a lamellar mesophase lipid component accounting for the birefringent property of the lesion; third, evidence from the present work makes it unlikely that the etiology of cholesterolosis is related to the process of human gallstone formation; last, chemical similarities are observable between the lipid composition of cholesterolosis lesions and the human intimal fatty streak lesion of atherosclerosis, despite the differences in lipid localization. |
| Databáze: | OpenAIRE |
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