Central nitrergic system regulation of neuroendocrine secretion, fluid intake and blood pressure induced by angiotensin-II

Autor: Antunes-Rodrigues J, Luiz Marcelo Aranha Camargo, W. A. Saad, Wagner Luiz Reis, Lucila Leico Kagohara Elias
Přispěvatelé: Elias, Lucila https://orcid.org/0000-0002-6271-758X, Reis, Wagner https://orcid.org/0000-0002-1980-8224, Elias, Lucila/P-6533-2015, Reis, Wagner/O-9656-2015, Universidade de São Paulo (USP), Universidade Estadual Paulista (Unesp), Univ Taubate UNITAU, Centro Univ Araraquara
Rok vydání: 2010
Předmět:
Male
Vasopressin
Blood Pressure
Urine
Oxytocin
lcsh:RC346-429
Thirst
Rats
Sprague-Dawley
Behavioral Neuroscience
Atrial natriuretic peptide
Hypovolemia
Cholinergic Stimulation
media_common
Hypothalamic Paraventricular Nucleus
Chemistry
Angiotensin II
Brain
General Medicine
NG-Nitroarginine Methyl Ester
medicine.symptom
Behavioral Sciences
Atrial Natriuretic Factor
hormones
hormone substitutes
and hormone antagonists
medicine.drug
medicine.medical_specialty
Vasopressins
Cognitive Neuroscience
media_common.quotation_subject
Drinking
Drinking Behavior
Gene-Expression
Arginine
Nitric Oxide
Natriuresis
Water-Deprivation
Internal medicine
Atrial-Natriuretic-Peptide
medicine
Animals
Rats
Wistar
Body-Fluid
lcsh:Neurology. Diseases of the nervous system
Biological Psychiatry
Injections
Intraventricular
Nadph-Diaphorase
Nitric-Oxide Synthase
Research
Sodium
Neurosciences
Appetite
Rats
Endocrinology
Conscious Rats
Neurosciences & Neurology
Zdroj: Web of Science
Repositório Institucional da UNITAU
Universidade de Taubaté (UNITAU)
instacron:UNITAU
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Behavioral and Brain Functions, Vol 6, Iss 1, p 64 (2010)
Behavioral and Brain Functions : BBF
Popis: Made available in DSpace on 2013-08-28T14:14:07Z (GMT). No. of bitstreams: 1 WOS000284277100001.pdf: 665170 bytes, checksum: 0887cff9d67cdf643e0025f69403d845 (MD5) Made available in DSpace on 2013-09-30T18:32:42Z (GMT). No. of bitstreams: 2 WOS000284277100001.pdf: 665170 bytes, checksum: 0887cff9d67cdf643e0025f69403d845 (MD5) WOS000284277100001.pdf.txt: 37148 bytes, checksum: 4ca4ff2e32c887320a13f9a1c1729981 (MD5) Previous issue date: 2010-10-25 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:46:12Z No. of bitstreams: 2 WOS000284277100001.pdf: 665170 bytes, checksum: 0887cff9d67cdf643e0025f69403d845 (MD5) WOS000284277100001.pdf.txt: 37148 bytes, checksum: 4ca4ff2e32c887320a13f9a1c1729981 (MD5) Made available in DSpace on 2014-05-20T13:46:12Z (GMT). No. of bitstreams: 2 WOS000284277100001.pdf: 665170 bytes, checksum: 0887cff9d67cdf643e0025f69403d845 (MD5) WOS000284277100001.pdf.txt: 37148 bytes, checksum: 4ca4ff2e32c887320a13f9a1c1729981 (MD5) Previous issue date: 2010-10-25 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Background: Nitric oxide (NO) synthesis has been described in several circumventricular and hypothalamic structures in the central nervous system that are implicated in mediating central angiotensin-II (ANG-II) actions during water deprivation and hypovolemia. Neuroendocrine and cardiovascular responses, drinking behavior, and urinary excretions were examined following central angiotensinergic stimulation in awake freely-moving rats pretreated with intracerebroventricular injections of N omega-nitro-L-arginine methyl ester (L-NAME, 40 mu g), an inhibitor of NO synthase, and L-arginine (20 ug), a precursor of NO.Results: Injections of L-NAME or ANG-II produced an increase in plasma vasopressin (VP), oxytocin (OT) and atrial natriuretic peptide (ANP) levels, an increase in water and sodium intake, mean arterial blood pressure and sodium excretion, and a reduction of urinary volume. L-NAME pretreatment enhanced the ANG-II response, while L-arginine attenuated VP and OT release, thirst, appetite for sodium, antidiuresis, and natriuresis, as well as pressor responses induced by ANG-II.Discussion and conclusion: Thus, the central nitrergic system participates in the angiotensinergic responses evoked by water deprivation and hypovolemia to refrain neurohypophysial secretion, hydromineral balance, and blood pressure homeostasis. Univ São Paulo, Sch Med Ribeirao Preto, Dept Physiol, Neuroendocrinol Lab, BR-14049 Ribeirao Preto, SP, Brazil Paulista State Univ Araraquara, UNESP, Sch Dent, Dept Physiol, Araraquara, SP, Brazil Univ Taubate UNITAU, Basic Inst Biosci, Taubate, SP, Brazil Centro Univ Araraquara, Dept Exact & Nat Sci, Araraquara, SP, Brazil Paulista State Univ Araraquara, UNESP, Sch Dent, Dept Physiol, Araraquara, SP, Brazil FAPESP: 98/15846-0 CNPq: 14544-00
Databáze: OpenAIRE
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