Fluorescence chemosensing of meldonium using a cross-reactive sensor array
| Autor: | Mehmet Gokhan Caglayan, Tugba Taskin-Tok, Cem Erkmen, Ergin Yalçın |
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| Přispěvatelé: | Mühendislik ve Doğa Bilimleri Fakültesi -- Mühendislik Temel Bilimleri Bölümü, Yalçın, Ergin |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Molecular Dynamics Simulation Molecular dynamics Biochemistry Fluorescence spectroscopy Analytical Chemistry Carnitine | Fatty Acids | Metabolism Absorption spectroscopy Sensor array Electrochemistry medicine Environmental Chemistry Humans Human urine Differential response Fluorescent sensors Microwaves Spectroscopy Nuclear magnetic resonance spectroscopy Fluorescent Dyes Meldonium Doping in Sports Scaffolds Ethidium bromide Mass spectrometry Molecular dynamics simulations World Anti-Doping Agency Discriminant Analysis Qualitative and quantitative analysis Hydrogen-Ion Concentration Analytical Ultraviolet visible absorption Fluorescence Interaction mechanisms Chemistry Spectrometry Fluorescence Mildronate Human plasma Thermodynamics Biological system medicine.drug Methylhydrazines |
| Popis: | In this paper, we report a fluorescent sensor array approach for the urinary detection of a prohibited substance in sports, meldonium. Four chemosensors with ethidium bromide scaffolds were employed in this method. The interaction between meldonium and chemosensors was investigated by different techniques, such as ultraviolet-visible absorption and fluorescence spectroscopy, nuclear magnetic resonance, and mass spectrometry. Molecular dynamics simulation was also used to elucidate and support the interaction mechanisms between meldonium and the chemosensors. Differential responses obtained from the sensor array enabled the qualitative and quantitative analyses of meldonium with low error values. This method was able to detect and quantify meldonium at the nM level, fulfilling the requirements of minimum performance defined by the World Anti-Doping Agency. © The Royal Society of Chemistry 2020. 117Z185 Türkiye Bilimsel ve Teknolojik Araştırma Kurumu The authors acknowledge the Scientific and Technological Research Council of Turkey (TUBITAK, project no.: 117Z185) for financial support. The authors also specially thank Dr Yesim Somay Selbes from the Turkish Doping Control Center and Prof. Dr Zeynel Seferoglu from Gazi University for their support. |
| Databáze: | OpenAIRE |
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