Brief Report: HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β
| Autor: | Dejene M. Tufa, Debanjana Chatterjee, Gerrit Ahrenstorf, Fareed Ahmad, Roland Jacobs, Reinhold E. Schmidt |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Interleukin-1beta Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Immune system Humans Medicine Pharmacology (medical) business.industry Case-control study Interleukin Dendritic Cells Middle Aged Viral Load Phenotype CD4 Lymphocyte Count 030104 developmental biology Infectious Diseases Case-Control Studies Immunology HIV-1 Female business Viral load Function (biology) 030215 immunology |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 73:34-38 |
| ISSN: | 1525-4135 |
| DOI: | 10.1097/qai.0000000000001082 |
| Popis: | HIV infection is marked by phenotypic and functional alterations of immune cells. Different studies have shown both numerical and functional deterioration of dendritic cells in HIV-1-infected patients. In this study, we report an increase of inflammatory 6-sulfo LacNAc dendritic cells (slanDCs) that are more activated and produce higher amounts of interleukin (IL)-1β during HIV-1 infection as compared with healthy controls. IL-1β plays a regulatory role in chronic inflammatory disorders. Therefore, our findings might reveal a compensatory regulatory function of slanDCs during HIV-1 infection. |
| Databáze: | OpenAIRE |
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