Bone metabolism, density, and geometry in postmenopausal women with vitamin D insufficiency: a cross-sectional comparison of the effects of elevated parathyroid levels

Autor: Tanja Sikjaer, Lise Sofie Bislev, Lars Rejnmark, Lene Langagergaard Rødbro
Rok vydání: 2018
Předmět:
Vitamin D/analogs & derivatives
0301 basic medicine
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Lumbar Vertebrae/physiopathology
Parathyroid hormone
030209 endocrinology & metabolism
Geometry
Bone and Bones/metabolism
Bone and Bones
Bone remodeling
03 medical and health sciences
Hyperparathyroidism
Secondary/etiology
Absorptiometry
Photon
0302 clinical medicine
BMD
Bone Density
Internal medicine
medicine
Vitamin D and neurology
Humans
Tibia
Vitamin D
Quantitative computed tomography
Cross-sectional study
Aged
Aged
80 and over
Bone mineral
Lumbar Vertebrae
biology
medicine.diagnostic_test
Bone geometry
business.industry
Middle Aged
Vitamin D Deficiency
Rheumatology
Cross-Sectional Studies
Parathyroid Hormone
Parathyroid Hormone/blood
Osteocalcin
biology.protein
Female
Hyperparathyroidism
Secondary
030101 anatomy & morphology
Bone Density/physiology
Vitamin D Deficiency/complications
Tomography
X-Ray Computed
business
PTH
Zdroj: Rødbro, L L, Bislev, L S, Sikjær, T & Rejnmark, L 2018, ' Bone metabolism, density, and geometry in postmenopausal women with vitamin D insufficiency : a cross-sectional comparison of the effects of elevated parathyroid levels ', Osteoporosis International, vol. 29, no. 10, pp. 2211-2218 . https://doi.org/10.1007/s00198-018-4602-x
ISSN: 1433-2965
0937-941X
DOI: 10.1007/s00198-018-4602-x
Popis: Increased levels of parathyroid hormone (PTH) may have adverse effects on bone health. In a cross-sectional design, we investigated this hypothesis among 102 postmenopausal vitamin D insufficient women. Elevated PTH was associated with altered bone geometry, decreased bone mineral density in the spine, and increased bone turnover.INTRODUCTION: In vitamin D insufficiency, elevated parathyroid hormone (PTH) levels may contribute to adverse effect on bone. We assessed effects of PTH responses to vitamin D insufficiency on bone metabolism, density, and geometry.METHODS: Using a cross-sectional design, we investigated 102 healthy postmenopausal women with low 25-hydroxy-vitamin D ( 6.9 pmol/L, N = 51) or normal PTH levels (N = 51). Bone mineral density (BMD) and bone geometry were assessed by Dual-Energy X-ray absorptiometry (DXA), quantitative computed tomography (QCT) and high-resolution peripheral QCT (HRpQCT) scans. Bone metabolism was assessed by biochemistry including bone turnover markers.RESULTS: Levels of 25(OH)D were 38 (IQR 31-45) nmol/L with no differences between groups. PTH levels were 8.5 (IQR 7.5-9.5) in women with SHPT and 5.2 (4.4-6.6) pmol/L in women with normal PTH (p CONCLUSIONS: High PTH levels are associated with altered bone geometry, increased bone turnover, and reduced BMD at the spine. Whether an increased cortical thickness with a lower trabecular volume is an effect of PTH or not needs further elucidations.
Databáze: OpenAIRE
Externí odkaz: