Deletion polymorphism in a Drosophila melanogaster heat shock gene
| Autor: | K, Sirotkin, N, Bartley, W L, Perry, D, Briggs, E H, Grell, C, Morganelli, E M, Berger, J J, Bonner, B, Leicht |
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| Rok vydání: | 1986 |
| Předmět: |
Genetics
Polymorphism Genetic Base Sequence Homozygote Wild type Locus (genetics) DNA Restriction Enzymes Biology biology.organism_classification Molecular biology Imaginal disc Drosophila melanogaster Genes Transcription (biology) Animals Coding region Chromosome Deletion Cloning Molecular Allele Molecular Biology Gene Alleles Heat-Shock Proteins |
| Zdroj: | Molecular and General Genetics MGG. 204:266-272 |
| ISSN: | 1432-1874 0026-8925 |
| DOI: | 10.1007/bf00425508 |
| Popis: | We have continued the transcriptional analysis of the region of cytological locus 67B that contains the four small heat shock genes and other genes. Transcription from one of the heat shock genes in the region, hsp 26, takes place during high temperature treatment and at certain developmental stages, without heat shock, in several tissues, such as imaginal discs and adult ovaries. Observations of unexpected products after nuclease protection experiments periments provided the first indication of what genomic blot experiments showed to be small deletions. The alleles containing the deletion are expressed at the same level as the wild type allele. The deletion shortens the protein product, implying that it is in the coding region. Furthermore, flies homozygous for one of the deletion alleles are viable. |
| Databáze: | OpenAIRE |
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