The effect of irradiation by ultraviolet light on ureido-pyrimidinone based biomaterials
| Autor: | Pieter C. M. M. Magusin, Jef A. J. M. Vekemans, A. J. H. Spiering, Yoko Nakano, Björne B. Mollet, Patricia Y. W. Dankers, E. W. Meijer |
|---|---|
| Přispěvatelé: | Chemical Biology, Macromolecular and Organic Chemistry, Macro-Organic Chemistry |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Polymers and Plastics
02 engineering and technology 010402 general chemistry Photochemistry 01 natural sciences photoreactive effects Polymer chemistry Materials Chemistry Ultraviolet light crosslinking Irradiation chemistry.chemical_classification tautomerization irradiation Chemistry Organic Chemistry Chemical modification Biomaterial ureido-pyrimidinone 021001 nanoscience & nanotechnology Tautomer Fluorescence 0104 chemical sciences Supramolecular polymers Solvent FT-IR fluorescence 0210 nano-technology supramolecular structures biomaterials |
| Zdroj: | Journal of Polymer Science, Part A: Polymer Chemistry, 54(1), 81-90. Wiley |
| ISSN: | 0887-624X |
| Popis: | Supramolecular polymers based on ureido-pyrimidinone (UPy) represent a promising class of biocompatible materials for medical applications. Here, the chemical modification effect of UV irradiation, used to sterilize these materials, is studied. Besides anticipated crosslinking effects, UV irradiation causes telechelic UPy-polymers to become fluorescent. UPy-model compounds confirm a relation between UV-induced changes and the UPy-moiety. UV-induced fluorescence and IR-spectral changes are (partially) reversible by heat and/or solvent treatment. The results indicate the presence of at least two distinct UV-induced molecular species. UPy-model compounds with specific tautomeric forms directly relate fluorescence to UPy-enol tautomers. Photo-enolization is hypothesized to occur via an excited-state intermolecular double proton transfer. Changes in UPy-tautomeric equilibrium and crosslinking are factors that influence the dynamics of UPy-based materials. Identification and understanding of such factors will aid in the successful application of these materials, for example as biomaterial in tissue engineering applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text