Base Mediated Synthesis of Alkyl-aryl Ethers from the Reaction of Aliphatic Alcohols and Unsymmetric Diaryliodonium Salts

Autor:	Sunil K. Sundalam, David R. Stuart
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Molecular Structure Base (chemistry) Aryl Biphenyl Compounds Organic Chemistry Substrate (chemistry) Salt (chemistry) Catalysis chemistry.chemical_compound Onium Compounds chemistry Alcohols Reagent Yield (chemistry) Electrophile Organic chemistry Alkyl Ethers
Zdroj:	The Journal of Organic Chemistry. 80:6456-6466
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.5b00907
Popis:	The base mediated coupling of aliphatic alcohol pronucleophiles with unsymmetric diaryliodonium salt electrophiles is described. This metal-free reaction is operationally simple, proceeds at mild temperature, and displays broad substrate scope to generate industrially important alkyl-aryl ethers in moderate to excellent yield. The synthetic utility of these reactions is demonstrated, and aspects of sustainability are highlighted by the use of unsymmetric aryl(mesityl)iodonium arylating reagents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829cf91fc01fa5c13cf4b47a83d1cabb https://doi.org/10.1021/acs.joc.5b00907 Zobrazit plný text záznamu