Feasibility Analysis of p62 (SQSTM1)—Encoding DNA Vaccine as a Novel Cancer Immunotherapy
| Autor: | Vladimir L. Gabai, Victor Shifrin |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_treatment
Immunology Review Biology Cancer Vaccines DNA vaccination Mice Dogs Immune system Antigen Cancer immunotherapy Antigens Neoplasm Neoplasms Sequestosome-1 Protein Autophagy Vaccines DNA medicine Animals Humans Immunology and Allergy Adaptor Proteins Signal Transducing transformation Immunotherapy Xenograft Model Antitumor Assays Tumor antigen Rats Immunoediting Cancer vaccine cancer vaccine tumor antigen Signal Transduction |
| Zdroj: | International Reviews of Immunology |
| ISSN: | 1563-5244 0883-0185 |
| Popis: | Cancer immunotherapy is a thriving field, but its clinical achievements are modest so far. One of its major hurdles seems to be finding a feasible cancer antigen as a target for immune response. After many years of research, three major criteria for choice of tumor antigens emerged. An antigen should be: (i) immunogenic; (ii) essential for cancers cells (to avoid its loss through immunoediting), but dispensable for normal tissues to reduce the risk of toxicity, and (iii) overexpressed in tumors as compared to the normal tissues. Here we argue that p62 (SQSTM1), a protein involved in autophagy and signal transduction, fits all the above criteria and can be chosen as a novel cancer antigen. Accordingly, we carried out an extensive study and found antitumor and antimetastatic activity of p62-encoding DNA vaccine in five types of commonly used transplantable tumor models of mice and rats, and spontaneous tumors in several dogs. Given that toxicity of p62 vaccine was minimal, if any, we believe that p62-encoding vaccine merits further clinical development. |
| Databáze: | OpenAIRE |
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