microRNA‑3941 targets IGF2 to control LPS‑induced acute pneumonia in A549 cells
| Autor: | Shinuan Fei, Liangzhi Pan, Lichun Cao |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Lipopolysaccharides Male Cancer Research Apoptosis Pharmacology Biochemistry Phosphatidylinositol 3-Kinases 0302 clinical medicine Genes Reporter RNA Small Interfering Child Luciferases Cell cycle Oncology 030220 oncology & carcinogenesis Child Preschool Acute Disease Molecular Medicine Tumor necrosis factor alpha Female medicine.symptom Signal Transduction Cell Survival Inflammation 03 medical and health sciences Insulin-Like Growth Factor II Genetics medicine Humans Molecular Biology Protein kinase B PI3K/AKT/mTOR pathway A549 cell Binding Sites Oligoribonucleotides Base Sequence business.industry Antagomirs Infant Pneumonia medicine.disease MicroRNAs 030104 developmental biology Gene Expression Regulation A549 Cells business Proto-Oncogene Proteins c-akt |
| Zdroj: | Molecular medicine reports. 17(3) |
| ISSN: | 1791-3004 |
| Popis: | The present study aimed to investigate the potential roles and regulatory mechanism of microRNA (miR)-3941 in lipopolysaccharides (LPS)‑induced acute pneumonia. The expression of miR‑3941 in child patients with acute pneumonia was detected and A549 cells were treated with LPS to establish the cellular model of acute pneumonia. The effects of miR‑3941 in LPS‑induced cell injury were investigated by assessing cell viability, apoptosis and inflammation. In addition, the regulatory relationship between miR‑3941 and insulin‑like growth factor 2 (IGF2) was explored, as well as the association between miR‑3941 and the phosphatidylinositol‑4,5‑bisphosphate 3‑kinase/protein kinase B (PI3K/AKT) pathway. miR‑3941 was significantly down‑regulated in patients with acute pneumonia (P |
| Databáze: | OpenAIRE |
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