Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface
| Autor: | Jack L. Strominger, Tamara Tilburgs, Errol R. Norwitz, Vidya Iyer, Marilen Benner, Vita Setrajcic-Dragos, Hannah Ananda Bougleux Gomes, Anita van der Zwan, Maria Salvany-Celades |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
CD4-Positive T-Lymphocytes
0301 basic medicine Placenta T cell Programmed Cell Death 1 Receptor chemical and pharmacologic phenomena HLA-C Antigens Biology T-Lymphocytes Regulatory General Biochemistry Genetics and Molecular Biology Immune tolerance 03 medical and health sciences Fetus All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine TIGIT Pregnancy HLA-G Decidua Immune Tolerance medicine Humans lcsh:QH301-705.5 Cells Cultured FOXP3 Trophoblast Forkhead Transcription Factors hemic and immune systems Interleukin-10 Trophoblasts Interleukin 10 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) embryonic structures Immunology Female Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5] 030217 neurology & neurosurgery |
| Zdroj: | Cell Reports, 27, 9, pp. 2537 Cell Reports, Vol 27, Iss 9, Pp 2537-2547.e5 (2019) Cell Reports, 27, 2537 |
| ISSN: | 2211-1247 |
| Popis: | Summary: During pregnancy, maternal regulatory T cells (Tregs) are important in establishing immune tolerance to invading fetal extravillous trophoblasts (EVTs). CD25HIFOXP3+ Tregs are found at high levels in decidual tissues and have been shown to suppress fetus-specific and nonspecific responses. However, limited data are available on additional decidual Treg types and the mechanisms by which they are induced. This study investigated three distinct decidual CD4+ Treg types in healthy pregnancies with a regulatory phenotype and the ability to suppress T cell responses: CD25HIFOXP3+, PD1HIIL-10+, and TIGIT+FOXP3dim. Moreover, co-culture of HLA-G+ EVTs or decidual macrophages with blood CD4+ T cells directly increased the proportions of CD25HIFOXP3+ Tregs compared to T cells cultured alone. EVTs also increased PD1HI Tregs that could be inhibited by HLA-C and CD3 antibodies, suggesting an antigen-specific induction. The presence of distinct Treg types may allow for the modulation of a variety of inflammatory responses in the placenta. : Salvany-Celades et al. refine the view of regulatory T cells (Treg) at the maternal-fetal interface by presenting phenotypic and functional data of three decidual Treg populations in human pregnancy. Extravillous trophoblasts and decidual macrophages directly increase Treg populations, and antigen specificity for HLA-C may be involved. Keywords: HLA-C, HLA-G, pregnancy, decidua, placenta, trophoblast, IL-10, immune tolerance, Trl cell, FOXP3 |
| Databáze: | OpenAIRE |
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