Review: Neural Mechanisms of Tinnitus and Hyperacusis in Acute Drug-Induced Ototoxicity
| Autor: | Yu-Chen Chen, Richard Salvi, Senthilvelan Manohar, Condon Lau, Kelly Radziwon, Dalian Ding, Ben Auerbach, Guang-Di Chen, Xiaopeng Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Auditory Pathways Hearing loss Hippocampus Audiology Auditory cortex Arousal 03 medical and health sciences Speech and Hearing Tinnitus 0302 clinical medicine Ototoxicity medicine otorhinolaryngologic diseases Animals Humans Cochlea 030304 developmental biology Auditory Cortex 0303 health sciences Special Issue: Selected Papers From the 9th Biennial National Center for Rehabilitative Auditory Research Conference business.industry Hyperacusis medicine.disease medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Am J Audiol |
| ISSN: | 1558-9137 |
| Popis: | PurposeTinnitus and hyperacusis are debilitating conditions often associated with age-, noise-, and drug-induced hearing loss. Because of their subjective nature, the neural mechanisms that give rise to tinnitus and hyperacusis are poorly understood. Over the past few decades, considerable progress has been made in deciphering the biological bases for these disorders using animal models.MethodImportant advances in understanding the biological bases of tinnitus and hyperacusis have come from studies in which tinnitus and hyperacusis are consistently induced with a high dose of salicylate, the active ingredient in aspirin.ResultsSalicylate induced a transient hearing loss characterized by a reduction in otoacoustic emissions, a moderate cochlear threshold shift, and a large reduction in the neural output of the cochlea. As the weak cochlear neural signals were relayed up the auditory pathway, they were progressively amplified so that the suprathreshold neural responses in the auditory cortex were much larger than normal. Excessive central gain (neural amplification), presumably resulting from diminished inhibition, is believed to contribute to hyperacusis and tinnitus. Salicylate also increased corticosterone stress hormone levels. Functional imaging studies indicated that salicylate increased spontaneous activity and enhanced functional connectivity between structures in the central auditory pathway and regions of the brain associated with arousal (reticular formation), emotion (amygdala), memory/spatial navigation (hippocampus), motor planning (cerebellum), and motor control (caudate/putamen).ConclusionThese results suggest that tinnitus and hyperacusis arise from aberrant neural signaling in a complex neural network that includes both auditory and nonauditory structures. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|