Age-Related Epstein-Barr Virus-Positive Lymphoproliferative Disorders of the Orbit and Maxillary Sinus : A Case Report
| Autor: | Momoko Mawatari, Shigeo Nakamura, Masamitsu Karasawa, Takeki Mitsui, Hiroshi Handa, Masaru Kojima, Junko Hirato, Akihiko Yokohama, Norifumi Tsukamoto, Yoshihisa Nojima, Takayuki Saitoh, Hirokazu Murakami, Hiromi Koiso, Hideki Uchiumi |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Epstein-Barr Virus Infections Herpesvirus 4 Human Pathology medicine.medical_specialty Maxillary sinus CD30 Gene Expression Lymphoproliferative disorders Diagnosis Differential stomatognathic system immune system diseases hemic and lymphatic diseases medicine Humans Reed-Sternberg Cells Lymph node Neoplasm Staging business.industry Lymphoma Non-Hodgkin Epstein-Barr Virus Positive General Medicine Maxillary Sinus Middle Aged Hodgkin's lymphoma medicine.disease Hodgkin Disease Immunohistochemistry Neoplasm Proteins Lymphoma medicine.anatomical_structure Giant cell business Orbit |
| Zdroj: | Journal of Clinical and Experimental Hematopathology. 52:205-209 |
| ISSN: | 1880-9952 1346-4280 |
| DOI: | 10.3960/jslrt.52.205 |
| Popis: | We report a rare case of age-related Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disorder (aEBVBLPD) primarily involving the orbit and maxillary sinus. Lesions in the left orbit and maxillary sinus were observed in a 59-year-old man presenting with pain in the left orbit and maxilla. Owing to the presence of Reed-Sternberg-like cells, the initial diagnosis was nodular sclerosis-type Hodgkin's lymphoma. Clinical stage was IIAE, and response to chemotherapy and radiotherapy was favorable. Further immunohistochemical and in situ hybridization analyses of the Reed-Sternberg-like giant cells revealed CD30, CD15, CD20, Bob-1, Oct-2, EBV-encoded RNAs (EBERs) and latent membrane protein-1 (LMP-1) expression. The characteristics of the present case, which included immunohistochemical findings, sites of primary lesions, absence of other lymph node lesions and relatively old age, suggested aEBVBLPD. Owing to the similarity in morphology, higher frequency at extranodal sites and poor prognosis, aEBVBLPD represents a differential diagnostic issue from classical Hodgkin's lymphoma when Reed-Sternberg cells are positive for EBV. |
| Databáze: | OpenAIRE |
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