Celiprolol, a Compound Which Attenuates Myocardial Acidosis and Improves Regional Segmental Function following Ischemia in Dogs: a Comparison with Propranolol
| Autor: | John A. Barrett, Peter S. Wolf, Ronald D. Smith, Thaddeus P. Pruss, Angela M. Magistro |
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| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Ischemia Hemodynamics Blood Pressure Coronary Disease Propranolol Body Temperature Propanolamines Electrocardiography Dogs Heart Rate Coronary Circulation Internal medicine Heart rate Animals Medicine ST segment Adrenergic alpha-Antagonists Celiprolol Acidosis Pharmacology business.industry General Medicine Hydrogen-Ion Concentration medicine.disease Blood pressure Anesthesia Cardiology Female medicine.symptom Cardiomyopathies business medicine.drug |
| Zdroj: | Pharmacology. 39:1-10 |
| ISSN: | 1423-0313 0031-7012 |
| DOI: | 10.1159/000138565 |
| Popis: | Celiprolol, propranolol or saline were administered to separate groups (n = 5-6) of anesthetized dogs in which a critical stenosis was applied to the circumflex coronary artery for 90 min and then reperfused for 30 min. Test drugs were administered at 30 min poststenosis and the effects on pH, regional function and endocardiogram were monitored. A reduction in coronary flow of 54 +/- 2% (n = 27) yielded marked increases in hydrogen ion concentration (H+) of 17 +/- 2 X 10(-8) and ischemic endocardial ST segment of 6 +/- 1 mV while ischemic segmental shortening decreased 75 +/- 9%. Heart rate, arterial pressure and normal regional function were not altered. Celiprolol 0.1 and 1 mg/kg, i.v., reversed the alterations in H+ and ischemic ST segment to prestenosis values while improving ischemic segmental shortening 20 and 38%, respectively, and not affecting heart rate. Propranolol 0.1 and 1 mg/kg, i.v., reversed the alterations in H+ and ischemic ST segment to prestenosis values while further decreasing ischemic segmental shortening 66 and 30%, respectively. Upon reperfusion, ischemic segmental shortening returned to prestenosis values in the group treated with celiprolol 1 mg/kg, i.v., while the propranolol- and saline-treated groups further decreased. It is concluded that celiprolol is efficacious in normalizing myocardial function and ischemia-induced electrophysiological changes following coronary artery stenosis. |
| Databáze: | OpenAIRE |
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