Inflammation-associated graft loss in renal transplant recipients

Autor: Gudrun E. Norby, Dag Olav Dahle, Björn Öqvist, Gisela Weihrauch, Winfried März, Alan G. Jardine, Tanja B. Grammer, Geir Mjøen, Ingar Holme, Sadollah Abedini, Hubert Scharnagl, Bengt Fellström, Hallvard Holdaas
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Graft Rejection
Male
Indoles
Kidney Function Tests
Fatty Acids
Monounsaturated
chemistry.chemical_compound
Postoperative Complications
Prospective Studies
Prospective cohort study
biology
Anticholesteremic Agents
Middle Aged
Prognosis
Survival Rate
C-Reactive Protein
surgical procedures
operative
Nephrology
Creatinine
allograft survival
Female
Kidney Diseases
medicine.symptom
Glomerular Filtration Rate
Adult
medicine.medical_specialty
Urology
Renal function
Inflammation
Double-Blind Method
high-sensitivity CRP
medicine
Humans
Transplantation
Homologous
Urology and Nephrology
Fluvastatin
Survival rate
Transplantation
Interleukin-6
Surrogate endpoint
business.industry
interleukin-6
C-reactive protein
Kidney Transplantation
Surgery
chemistry
inflammation
ALERT
biology.protein
renal
business
Follow-Up Studies
Zdroj: Nephrology Dialysis Transplantation; 26(11), pp 3756-3761 (2011)
ISSN: 1460-2385
Popis: Background. Although short-term graft survival has improved substantially in renal transplant recipients, long-term graft survival has not improved over the last decades. The lack of knowledge of specific causes and risk factors has hampered improvements in long-term allograft survival. There is an uncertainty if inflammation is associated with late graft loss. Methods. We examined, in a large prospective trial, the inflammation markers high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) and their association with chronic graft dysfunction. We collected data from the Assessment of Lescol in Renal Transplant trial, which recruited 2102 maintenance renal transplant recipients. Results. Baseline values were hsCRP 3.8 +/- 6.7 mg/L and IL-6 2.9 +/- 1.9 pg/mL. Adjusted for traditional risk factors, hsCRP and IL-6 were independently associated with death-censored graft loss, the composite end points graft loss or death and doubling of serum creatinine, graft loss or death. Conclusion. The inflammation markers hsCRP and IL-6 are associated with long-term graft outcomes in renal transplant recipients.
Databáze: OpenAIRE
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