Design of porous Eudragit® L beads for floating drug delivery by wax removal technique
| Autor: | Prasert Akkaramongkolporn, Tassanee Nernplod, Kampanart Huanbutta, Pornsak Sriamornsak |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pharmaceutical Science
Eudragit® L 02 engineering and technology 030226 pharmacology & pharmacy Matrix (chemical analysis) 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Porous beads medicine Acetone White petrolatum Dichloromethane chemistry.chemical_classification Pharmacology Wax Wax removal Chromatography Cetyl alcohol lcsh:RM1-950 Polymer 021001 nanoscience & nanotechnology medicine.drug_formulation_ingredient lcsh:Therapeutics. Pharmacology chemistry Floating visual_art Drug delivery visual_art.visual_art_medium 0210 nano-technology |
| Zdroj: | Asian Journal of Pharmaceutical Sciences, Vol 12, Iss 3, Pp 227-234 (2017) |
| ISSN: | 1818-0876 |
| DOI: | 10.1016/j.ajps.2016.12.002 |
| Popis: | The aim of this study was to design porous matrix beads for floating drug delivery using enteric polymer, Eudragit® L and various amounts of waxes (0, 0.1, 0.5, 1, 2 and 3% w/w). In this study, wax containing cetyl alcohol and white petrolatum was utilized to produce pores using a wax removal technique. To prepare the beads, Eudragit® L, metronidazole and wax were dissolved in acetone and then extruded into dichloromethane. The effect of the amount of wax on the floating and drug release behavior of the Eudragit® L beads was determined. After the extruded product was immersed in dichloromethane, wax dissolved out from the formed beads, resulting in a porous structure. The prepared beads could float in simulated gastric fluid for more than 10 hours. Different amounts of wax had an effect on the drug release. We found that when the percentage of wax increased, the drug release was higher while the beads remained floating. The results suggest that Eudragit® L beads could be used as a carrier for an intragastric floating drug delivery system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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