Hormone receptors do not predict the HER2/neu status in all age groups of women with an operable breast cancer
| Autor: | H. Wildiers, Ignace Vergote, Patrick Neven, Robert Paridaens, E. Van Limbergen, M. Drijkoningen, Frédéric Amant, H. J. Huang, Patrick Berteloot, M-R Christiaens |
|---|---|
| Přispěvatelé: | Academic Medical Center |
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Receptor ErbB-2 Estrogen receptor Breast Neoplasms HER2/Neu Status HER2/neu Breast cancer Age Distribution Internal medicine Progesterone receptor medicine Biomarkers Tumor Humans Neoplasm Invasiveness skin and connective tissue diseases Receptor Aged Neoplasm Staging Retrospective Studies biology business.industry Hematology Middle Aged medicine.disease Gene Expression Regulation Neoplastic Endocrinology Oncology Receptors Estrogen Estrogen Hormone receptor biology.protein Female Lymph Nodes business Receptors Progesterone |
| Zdroj: | Annals of oncology, 16(11), 1755-1761. Oxford University Press |
| ISSN: | 0923-7534 |
| Popis: | In breast cancer, there is an inverse relationship between HER2/neu overexpression and receptors for estrogen (ER) or progesterone (PR). Some clinical observations such as the age-related association between hormone receptors and tumour grade, which predicts HER2/neu overexpression, suggest an age-related relationship. Our study population consisted of 1362 consecutive women receiving primary surgery for non-metastatic invasive breast cancer. We compared the relationship between both hormone receptors and HER2/neu overexpression in different age groups taking other tumour characteristics into account. In a multivariate model, considering the overall group, a negative ER, a negative PR and a high tumour grade were predictive for HER2/neu overexpression (P 45 years, ER (P = 0.001), PR (P = 0.001) and tumour grade (P |
| Databáze: | OpenAIRE |
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