Delivery of Probiotic to Microbiome by Layer-by-Layer Encapsulation

Autor: D. H. Shokatayeva, Irina Savitskaya, L. V. Ignatova, M. A. Abdulzhanova, Alexander D. Pogrebnjak, Aida Kistaubayeva
Rok vydání: 2019
Předmět:
Zdroj: Springer Proceedings in Physics ISBN: 9789811539954
DOI: 10.1109/nap47236.2019.216929
Popis: The probiotic alginate microcapsules of a matrix type were obtained by extrusion method. The coating with an additional layer (layer-by-layer) was carried out by placing the alginate microcapsules with bacteria included in them in a 0.4% solution of chitosan or pullulan. Microcapsules look like spherical particles, white, with a smooth surface. The size of microcapsules is 102–145 microns. The efficiency of L. acidophilus AA-1 cells immobilization for uncoated (alginate) and coated with chitosan and pullulan microcapsules was 96.35±1.65; 95.28±2.31 and 94.43±2.31, respectively. The survival rate of strains encapsulated in alginate-chitosan and alginate-pullan under model gastrointestinal conditions in vitro increased on average by 50-70% compared with free cells.
Databáze: OpenAIRE