The involvement of exosomes in the diagnosis and treatment of pancreatic cancer
| Autor: | X.L. Yang, Umwali Yvette, Chuanxin Wang, Abakundana Nsenga Ariston Gabriel, Yunshan Wang, Qinlian Jiao, Samed Ahmed Al-Ezzi Al-Ameri, Lutao Du, Fang Wang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Angiogenesis Review Biology Exosomes lcsh:RC254-282 Metastasis Extracellular Vesicles 03 medical and health sciences 0302 clinical medicine Mediator Pancreatic cancer microRNA Biomarkers Tumor Tumor Microenvironment medicine Humans RNA Messenger Cell Proliferation Cell growth Biomarker lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Microvesicles Gene Expression Regulation Neoplastic Pancreatic Neoplasms Treatment MicroRNAs 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research Molecular Medicine |
| Zdroj: | Molecular Cancer Molecular Cancer, Vol 19, Iss 1, Pp 1-9 (2020) |
| ISSN: | 1476-4598 |
| Popis: | At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act as the most prominent mediator of intercellular communication, and they regulate, instruct, and re-educate their surrounding microenvironment and target specific organs. Due to accumulative evidence proved that exosomes are involved in metastasis, cell proliferation, EMT, angiogenesis, and TME of pancreatic cancer, exosomes are crucial potential candidates to detect pancreatic cancer early. This review aims to convey the current understanding of the main functions employed by exosomes in early diagnosis and treatment of pancreatic cancer. |
| Databáze: | OpenAIRE |
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