Introducing ATR-FTIR Spectroscopy through Analysis of Acetaminophen Drugs: Practical Lessons for Interdisciplinary and Progressive Learning for Undergraduate Students
| Autor: | Carmen García-Ruiz, Gemma Montalvo, Félix Zapata, Gloria Quintanilla, Fernando Ortega-Ojeda, Adrián López-Fernández |
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| Přispěvatelé: | Universidad de Alcalá. Departamento de Física y Matemáticas, Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá. Departamento de Química Orgánica y Química Inorgánica |
| Rok vydání: | 2020 |
| Předmět: |
IR Spectroscopy
Computer science Management science Drugs/Pharmaceuticals Solid-state Atr ftir spectroscopy Infrared spectroscopy General Chemistry Hands-On Learning/Manipulatives Química Experimental laboratory Upper-Division Undergraduate Forensic Chemistry Education Analytical Chemistry Chemometrics Chemistry Graduate students Statistical analysis Undergraduate Research Qualitative Analysis Laboratory Equipment/Apparatus |
| Zdroj: | e_Buah Biblioteca Digital Universidad de Alcalá instname |
| ISSN: | 0021-9584 |
| Popis: | Infrared (IR) spectroscopy is a vibrational spectroscopic technique useful in chemical, pharmaceutical, and forensic sciences. It is essential to identify chemicals for reasons spanning from scientific research and academic practices to quality control in companies. However, in some university degrees, graduate students do not get the proficiency to optimize the experimental parameters to obtain the best IR spectra; to correlate the IR spectral bands with the molecular vibrations (chemical elucidation); to have some criteria for any substance identification (especially relevant in quality control to recognize counterfeit); and to apply chemometrics for comparing, visualizing, and classifying the IR spectra. This work presents an experimental laboratory practice for an introductory teaching of the IR instrumental conditions in the identification of substances based on visual spectra comparison and statistical analysis and matching. Then, the selected IR conditions are applied to different commercial drugs, in the solid state or insolution, mostly composed of acetaminophen. Finally, the students apply chemometrics analysis to the IR data. This practice was designed for the training in a chemistry subject for undergraduate students of the chemistry, pharmacy, or forensics degrees, among others related to science, medical, food, or technological sciences. Instituto Universitario de Investigación en Ciencias Policiales (IUICP) |
| Databáze: | OpenAIRE |
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