The p53 tumor suppressor network in cancer and the therapeutic modulation of cell death
| Autor: | Lynnelle Thorpe, Nicole L. Pinaire, Mark J. Routbort, Nikhil S. Chari, L. Jeffrey Medeiros, Timothy J. McDonnell |
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| Rok vydání: | 2009 |
| Předmět: |
Cancer Research
Programmed cell death Clinical Biochemistry Pharmaceutical Science Context (language use) Antineoplastic Agents Apoptosis Biology medicine.disease_cause Models Biological Metastasis Neoplasms microRNA medicine Animals Humans Pharmacology Cell Death Cell growth Biochemistry (medical) Cancer Cell Biology medicine.disease Cell biology Cancer research Tumor Suppressor Protein p53 Carcinogenesis |
| Zdroj: | Apoptosis : an international journal on programmed cell death. 14(4) |
| ISSN: | 1573-675X |
| Popis: | The molecular subversion of cell death is acknowledged as a principal contributor to the development and progression of cancer. The p53 tumor suppressor protein is among the most commonly altered proteins in human cancer. The p53 protein mediates critical functions within cells including the response to genotoxic stress, differentiation, senescence, and cell death. Loss of p53 function can result in enhanced rates of cell proliferation, resistance to cell death stimuli, genomic instability, and metastasis. The community of cancer scientists is now in possession of a vast repository of information regarding the frequency, specific mechanisms, and clinical context of cell death deregulation in cancer. This information has enabled the design of therapeutic agents to target proteins, including p53. The feasibility and impact of targeting cell death signaling proteins has been established in preclinical models of human cancer. The appropriate application of these targeted agents is now being established in clinical trials. |
| Databáze: | OpenAIRE |
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