Panax ginseng Leaf Extracts Exert Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats

Autor: Ju-Ock Nam, Yoon Jeong Lee, Myeong-Hwan Jang, Seul Lee, Tae Ryong Kwon
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
anti-obesity
Peroxisome proliferator-activated receptor
Adipose tissue
Rats
Sprague-Dawley
Ginseng
chemistry.chemical_compound
Mice
0302 clinical medicine
Adipocytes
leaf extracts
3T3-L1 adipocytes
anti-adipogenic
Panax ginseng
Receptor
chemistry.chemical_classification
Nutrition and Dietetics
Adipogenesis
food and beverages
Cell Differentiation
Cholesterol
030220 oncology & carcinogenesis
lcsh:Nutrition. Foods and food supply
medicine.medical_specialty
Cell Survival
Panax
lcsh:TX341-641
Biology
Diet
High-Fat
Article
03 medical and health sciences
In vivo
Internal medicine
3T3-L1 Cells
medicine
CCAAT-Enhancer-Binding Protein-alpha
Animals
Obesity
Triglycerides
Plant Extracts
medicine.disease
Rats
PPAR gamma
Plant Leaves
Disease Models
Animal
030104 developmental biology
Endocrinology
chemistry
Anti-Obesity Agents
Food Science
Zdroj: Nutrients
Nutrients, Vol 9, Iss 9, p 999 (2017)
Nutrients; Volume 9; Issue 9; Pages: 999
ISSN: 2072-6643
Popis: Recent studies have reported that the aerial parts of ginseng contain various saponins, which have anti-oxidative, anti-inflammatory, and anti-obesity properties similar to those of ginseng root. However, the leaf extracts of Korean ginseng have not yet been investigated. In this study, we demonstrate the anti-obesity effects of green leaf and dried leaf extracts (GL and DL, respectively) of ginseng in high-fat diet (HFD)-induced obese rats. The administration of GL and DL to HFD-induced obese rats significantly decreased body weight (by 96.5% and 96.7%, respectively), and epididymal and abdominal adipose tissue mass. Furthermore, DL inhibited the adipogenesis of 3T3-L1 adipocytes through regulation of the expression of key adipogenic regulators, such as peroxisome proliferator-activated receptor (PPAR)-γ and CCAAT/enhancer-binding protein (C/EBP)-α. In contrast, GL had little effect on the adipogenesis of 3T3-L1 adipocytes but greatly increased the protein expression of PPARγ compared with that in untreated cells. These results were not consistent with an anti-obesity effect in the animal model, which suggested that the anti-obesity effect of GL in vivo resulted from specific factors released by other organs, or from increased energy expenditure. To our knowledge, these findings are the first evidence for the anti-obesity effects of the leaf extracts of Korean ginseng in vivo.
Databáze: OpenAIRE
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