Osmotic behavior of normal and leukemic lymphocytes

Autor:	Zvi Bentwich, R Shaviv, Shmuel A. Ben-Sasson, Shimon Slavin, F Doljanski
Rok vydání:	1975
Předmět:	medicine.medical_specialty Lymphocyte Immunology Cell volume Osmotic swelling Cell Biology Hematology Biology Chronic lymphatic leukemia Biochemistry Peripheral blood Endocrinology medicine.anatomical_structure Nucleated cell Internal medicine medicine Tonicity Recovery phase
Zdroj:	Blood. 46:891-899
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood.v46.6.891.891
Popis:	The response of normal human peripheral blood lymphocytes to a hypotonic environment may be divided into two phases: the cells first exhibit rapid osmotic swelling, followed by a slower shrinking phase, during which they regain their initial physiologic volume. This osmotic behavior is characteristic of most mammalian and avian nucleated cells so far examined. The normal human blood lymphocyte, however, shows the most rapid recovery phase (5 min). Lymphocytes from chronic lymphatic leukemia patients, in comparison, show a strikingly slower rate of return to their initial isotonic volumes. The mechanism underlying osmotic cell volume regulation and its significance are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828d530aa43352608d55008e334b3ceb https://doi.org/10.1182/blood.v46.6.891.891 Zobrazit plný text záznamu