Antiglycation and antioxidant activity of four Iranian medical plant extracts
Autor: | Omid Azizi, Nejat Kheiripour, Mohammad Reza Safari, Alireza Pouyandeh Ravan, Somayeh Sadat Heidary |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Glycosylation Antioxidant medicine.medical_treatment lcsh:Medicine Antioxidants 03 medical and health sciences chemistry.chemical_compound Diabetes mellitus Glycation medicine Potency Bovine serum albumin lcsh:Miscellaneous systems and treatments Pharmacology Traditional medicine biology Fumaria officinalis lcsh:R lcsh:RM1-950 fungi Albumin food and beverages lcsh:RZ409.7-999 medicine.disease biology.organism_classification lcsh:Therapeutics. Pharmacology 030104 developmental biology Complementary and alternative medicine chemistry biology.protein Original Article |
Zdroj: | Journal of Pharmacopuncture Journal of Pharmacopuncture, Vol 21, Iss 2, Pp 82-89 (2018) |
ISSN: | 2234-6856 2093-6966 |
DOI: | 10.3831/kpi.2018.21.010 |
Popis: | Objective: Diabetes mellitus (DM) is the most common metabolic disorder that defined by chronic hyperglycemia for the deficiency in insulin secretion or resistance. Hyperglycemia could induce non-enzymatic glycation of proteins. It has been suggested that some traditional plants can improve blood glucose and inhibit glycation process. This work evaluates and compares the anti-glycation activities of four Iranian plant extracts in vitro. Methods: The methanolic extract of "Fumaria officinalis, Stachys lavandulifolia, Salvia hydrangea and Rosa Damascene" was prepared in three different concentrations. Phenolic, flavonoids content and antioxidant activity were evaluated. The multistage glycation markers- fructosamines (early stage), protein carbonyls (intermediate stage) and squared minus aggregation of albumin were investigated in the bovine serum albumin (BSA)/ glucose systemt. Results: All plants showed the high potency of scavenging free radicals and glycation inhibition in the following order: Fumaria officinalis > Rosa Damascene > Stachys lavandulifolia > Salvia hydrangea. There was a significant correlation between antioxidant and anti-glycation activity. Also, the antioxidant and anti-glycation capacity of extracts correlated with total phenolic and flavonoids content. Conclusion: Our findings demonstrated that the studied plants are good sources of anti-glycation and antioxidant compounds and, these properties can primarily attributable to phenolics, particularly flavonoids. © 2018 Korean Pharmacopuncture Institute. |
Databáze: | OpenAIRE |
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