Responders to Exercise Therapy in Patients with Osteoarthritis of the Hip: A Systematic Review and Meta-Analysis
| Autor: | Marienke van Middelkoop, Jos Runhaar, C.H. Teirlinck, Leontien M van Ravesteyn, Elja A E Reijneveld, Sita M A Bierma-Zeinstra, Arianne P. Verhagen, Lotte Hermsen, Ingrid B de Groot |
|---|---|
| Přispěvatelé: | General Practice, Orthopedics and Sports Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Health Toxicology and Mutagenesis lcsh:Medicine Osteoarthritis Review Q1 Toxicology responders Osteoarthritis Hip law.invention 03 medical and health sciences 0302 clinical medicine RC925 Randomized controlled trial RA0421 law Internal medicine medicine Humans 030212 general & internal medicine 030203 arthritis & rheumatology Clinical Trials as Topic exercise therapy business.industry lcsh:R Public Health Environmental and Occupational Health Absolute risk reduction R735 Exercise therapy medicine.disease R1 Confidence interval Rheumatology meta-analysis Treatment Outcome Meta-analysis hip osteoarthritis Number needed to treat business RA |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 17, Iss 7380, p 7380 (2020) International Journal of Environmental Research and Public Health, 17(20):7380. Multidisciplinary Digital Publishing Institute (MDPI) International Journal of Environmental Research and Public Health |
| ISSN: | 1661-7827 1660-4601 |
| DOI: | 10.3390/ijerph17207380 |
| Popis: | The Outcome Measures in Rheumatology workgroup (OMERACT), together with the Osteoarthritis Research Society International (OARSI) developed the OMERACT-OARSI responder criteria. These criteria are used to determine if a patient with osteoarthritis (OA) ‘responds’ to therapy, meaning experiences a clinically relevant effect of therapy. Recently, more clinical OA trials report on this outcome and most OA trials have data to calculate the number of responders according to these criteria. A systematic review and meta-analysis were performed on the response to exercise therapy, compared to no or minimal intervention in patients with hip OA using the OMERACT-OARSI responder criteria. The literature was searched for relevant randomized trials. If a trial fit the inclusion criteria, but number of responders was not reported, the first author was contacted. This way the numbers of responders of 14 trials were collected and a meta-analysis on short term (directly after treatment, 12 trials n = 1178) and long term (6–8 months after treatment, six trials n = 519) outcomes was performed. At short term, the risk difference (RD) was 0.14 (95% confidence interval (CI) 0.06–0.22) and number needed to treat (NNT) 7.1 (95% CI 4.5–17); at long term RD was 0.14 (95% CI 0.07–0.20) and NNT 7.1 (95% CI 5.0–14.3). Quality of evidence was moderate for the short term and high for the long term. In conclusion, 14% more hip OA patients responded to exercise therapy than to no therapy. |
| Databáze: | OpenAIRE |
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