Surgical Outcomes in Patients With Centrally Located Non-small Cell Lung Cancer
| Autor: | Hiroaki Komatsu, T. Kimura, Nobuhiro Izumi, Hidetoshi Inoue, Ryuichi Ito, Noritoshi Nishiyama, Takuma Tsukioka, Yumi Matsuda |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Lung Neoplasms medicine.medical_treatment General Biochemistry Genetics and Molecular Biology Pneumonectomy Carcinoma Non-Small-Cell Lung Internal medicine medicine Humans In patient Stage (cooking) Lung cancer Pathological Neoplasm Staging Retrospective Studies Pharmacology business.industry Sleeve Lobectomy medicine.disease Treatment Outcome T-stage Non small cell business Research Article |
| Zdroj: | In Vivo |
| ISSN: | 1791-7549 0258-851X |
| Popis: | Background/aim Identification of prognostic factors is helpful in selecting optimal treatment for centrally-located non-small cell lung cancer (NSCLC). This study aimed to detect prognostic factors in patients with centrally-located NSCLC. Patients and methods NSCLCs in the hilar area requiring pneumonectomy or sleeve lobectomy for complete removal are defined as centrally-located NSCLCs. We retrospectively investigated the clinical courses of 45 patients with such lesions. Results Sleeve lobectomies were performed on 33 patients and pneumonectomies on 12. Three and five-year survival rates were 72% and 62%, respectively. Presence of comorbidities (p=0.013), severe symptoms (p=0.001), high white cell count (p=0.001), and pathological T3-4 stage (p=0.004) were identified as independent predictors of poor prognosis. Operative procedures did not correlate with outcomes (p=0.722). Conclusion Presence of comorbidities, severe symptoms, high white cell counts, and pathological T stage are independent predictors of poor prognosis. These data can contribute in selecting appropriate treatments for such lesions. |
| Databáze: | OpenAIRE |
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