A mathematical model for dynamics of soluble form of DNAM-1 as a biomarker for graft-versus-host disease

Autor: Kazuko Shibuya, Akira Shibuya, Hisashi Sakamaki, Kazuteru Ohashi, Yuki Goshima, Shinji Nakaoka
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Antigens
Differentiation
T-Lymphocyte
Male
Cell Transplantation
medicine.medical_treatment
CD226
T-Lymphocytes
Graft vs Host Disease
Hematopoietic stem cell transplantation
Pathogenesis
Pathology and Laboratory Medicine
Biochemistry
White Blood Cells
0302 clinical medicine
Mathematical and Statistical Techniques
Animal Cells
immune system diseases
hemic and lymphatic diseases
Medicine and Health Sciences
Blood and Lymphatic System Procedures
Lymphocytes
Bone Marrow Transplantation
Multidisciplinary
Mathematical Models
T Cells
Statistics
Hematopoietic Stem Cell Transplantation
Middle Aged
Donor Lymphocytes
Prognosis
Killer Cells
Natural
surgical procedures
operative
Physical Sciences
Biomarker (medicine)
Medicine
Female
Cellular Types
Half-Life
Research Article
Adult
Immune Cells
Science
Immunology
Surgical and Invasive Medical Procedures
Research and Analysis Methods
03 medical and health sciences
Antigen
medicine
Humans
Transplantation
Homologous
Statistical Methods
Retrospective Studies
Transplantation
Blood Cells
business.industry
dNaM
Biology and Life Sciences
Cell Biology
Models
Theoretical
medicine.disease
030104 developmental biology
Graft-versus-host disease
Multivariate Analysis
business
Biomarkers
Mathematics
030215 immunology
Stem Cell Transplantation
Zdroj: PLoS ONE, Vol 15, Iss 2, p e0228508 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: DNAM-1 (CD226) is an activating immunoreceptor expressed on T cells and NK cells and involved in the pathogenesis of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We previously reported that a soluble form of DNAM-1 (sDNAM-1) is generated by shedding from activated T cells. Moreover, higher serum levels of sDNAM-1 in patients before allo-HSCT is a predictive biomarker for the development of aGVHD based on the retrospective univariate and multivariate analyses in allo-HSCT patients. However, it remains unclear how the serum levels of sDNAM-1 are regulated after allo-HSCT and whether they are associated with the development of aGVHD. Here, we constructed a mathematical model to assess the dynamics of sDNAM-1 after allo-HSCT by assuming that there are three types of sDNAM-1 (the first and the second were from alloreactive and non-alloreactive donor lymphocytes, respectively, and the third from recipient lymphocytes). Our mathematical model fitted well to the data set of sDNAM-1 in patients (n = 67) who had undergone allo-HSCT and suggest that the high proportion of the first type of sDNAM-1 to the total of the first and second types is associated with high risk of the development of severe aGVHD. Thus, sDNAM-1 after allo-HSCT can be a biomarker for the development of aGVHD.
Databáze: OpenAIRE
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