A mathematical model for dynamics of soluble form of DNAM-1 as a biomarker for graft-versus-host disease
Autor: | Kazuko Shibuya, Akira Shibuya, Hisashi Sakamaki, Kazuteru Ohashi, Yuki Goshima, Shinji Nakaoka |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Antigens Differentiation T-Lymphocyte Male Cell Transplantation medicine.medical_treatment CD226 T-Lymphocytes Graft vs Host Disease Hematopoietic stem cell transplantation Pathogenesis Pathology and Laboratory Medicine Biochemistry White Blood Cells 0302 clinical medicine Mathematical and Statistical Techniques Animal Cells immune system diseases hemic and lymphatic diseases Medicine and Health Sciences Blood and Lymphatic System Procedures Lymphocytes Bone Marrow Transplantation Multidisciplinary Mathematical Models T Cells Statistics Hematopoietic Stem Cell Transplantation Middle Aged Donor Lymphocytes Prognosis Killer Cells Natural surgical procedures operative Physical Sciences Biomarker (medicine) Medicine Female Cellular Types Half-Life Research Article Adult Immune Cells Science Immunology Surgical and Invasive Medical Procedures Research and Analysis Methods 03 medical and health sciences Antigen medicine Humans Transplantation Homologous Statistical Methods Retrospective Studies Transplantation Blood Cells business.industry dNaM Biology and Life Sciences Cell Biology Models Theoretical medicine.disease 030104 developmental biology Graft-versus-host disease Multivariate Analysis business Biomarkers Mathematics 030215 immunology Stem Cell Transplantation |
Zdroj: | PLoS ONE, Vol 15, Iss 2, p e0228508 (2020) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | DNAM-1 (CD226) is an activating immunoreceptor expressed on T cells and NK cells and involved in the pathogenesis of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We previously reported that a soluble form of DNAM-1 (sDNAM-1) is generated by shedding from activated T cells. Moreover, higher serum levels of sDNAM-1 in patients before allo-HSCT is a predictive biomarker for the development of aGVHD based on the retrospective univariate and multivariate analyses in allo-HSCT patients. However, it remains unclear how the serum levels of sDNAM-1 are regulated after allo-HSCT and whether they are associated with the development of aGVHD. Here, we constructed a mathematical model to assess the dynamics of sDNAM-1 after allo-HSCT by assuming that there are three types of sDNAM-1 (the first and the second were from alloreactive and non-alloreactive donor lymphocytes, respectively, and the third from recipient lymphocytes). Our mathematical model fitted well to the data set of sDNAM-1 in patients (n = 67) who had undergone allo-HSCT and suggest that the high proportion of the first type of sDNAM-1 to the total of the first and second types is associated with high risk of the development of severe aGVHD. Thus, sDNAM-1 after allo-HSCT can be a biomarker for the development of aGVHD. |
Databáze: | OpenAIRE |
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