Short leukocyte telomere length is associated with obesity in American Indians: the Strong Heart Family study
| Autor: | Barbara V. Howard, Tet Matsuguchi, Jinying Zhao, Fawn Yeh, Elisa T. Lee, Jue Lin, Elizabeth H. Blackburn, Shufeng Chen |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Gerontology
Adult Male Aging obesity Multivariate analysis Waist Adolescent Disease 030204 cardiovascular system & hematology 03 medical and health sciences Young Adult 0302 clinical medicine Diabetes mellitus medicine Leukocytes Humans strong heart family study cardiovascular diseases Risk factor 030304 developmental biology Aged 2. Zero hunger Aged 80 and over 0303 health sciences Anthropometry business.industry American Indians Cell Biology Middle Aged Telomere medicine.disease Obesity Leukocyte telomere length 3. Good health High-Throughput Screening Assays Indians North American Female business Body mass index Demography Research Paper |
| Zdroj: | Aging (Albany NY) Blackburn, Elizabeth; Chen, S; Yeh, F; Lin, J; Matsuguchi, T; Lee, ET; et al.(2014). Short leukocyte telomere length is associated with obesity in American Indians: The strong heart family study. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8hg0n2gd |
| ISSN: | 1945-4589 |
| Popis: | Shorter leukocyte telomere length (LTL) has been associated with a wide range of age-related disorders including cardiovascular disease (CVD) and diabetes. Obesity is an important risk factor for CVD and diabetes. The association of LTL with obesity is not well understood. This study for the first time examines the association of LTL with obesity indices including body mass index, waist circumference, percent body fat, waist-to-hip ratio, and waist-to-height ratio in 3,256 American Indians (14-93 years old, 60% women) participating in the Strong Heart Family Study. Association of LTL with each adiposity index was examined using multivariate generalized linear mixed model, adjusting for chronological age, sex, study center, education, lifestyle (smoking, alcohol consumption, and total energy intake), high-sensitivity C-reactive protein, hypertension and diabetes. Results show that obese participants had significantly shorter LTL than non-obese individuals (age-adjusted P=0.0002). Multivariate analyses demonstrate that LTL was significantly and inversely associated with all of the studied obesity parameters. Our results may shed light on the potential role of biological aging in pathogenesis of obesity and its comorbidities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|