Skeletal muscle and cardiovascular adaptations to exercise conditioning in older coronary patients
| Autor: | Kevin O. Leslie, Eric T. Poehlman, Martin M. LeWinter, Philip A. Ades, William L. Meyer, William W. Pendlebury, Mary L. Waldmann, Kenneth A. Brown, Peter R. Gray, Richard Lew |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Cardiac output medicine.medical_specialty Aging Physical exercise Coronary Disease Cardiovascular System Oxygen Consumption Reference Values Physiology (medical) Internal medicine Arteriovenous oxygen difference medicine Aerobic exercise Humans Myocardial infarction Muscle Skeletal Aerobic capacity Aged Aged 80 and over Physical Education and Training business.industry Stroke Volume Stroke volume Middle Aged medicine.disease Adaptation Physiological Physical therapy Cardiology Aerobic conditioning Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 94(3) |
| ISSN: | 0009-7322 |
| Popis: | Background Older coronary patients suffer from a low functional capacity and high rates of disability. Supervised exercise programs improve aerobic capacity in middle-aged coronary patients by improving both cardiac output and peripheral extraction of oxygen. Physiological adaptations to aerobic conditioning, however, have not been well studied in older coronary patients. Methods and Results The effect of a 3-month and a 1-year program of intense aerobic exercise was studied in 60 older coronary patients (mean age, 68±5 years) beginning 8±5 weeks after myocardial infarction or coronary bypass surgery. Outcome measures included peak aerobic capacity, cardiac output, arteriovenous oxygen difference, hyperemic calf blood flow, and skeletal muscle fiber morphometry, oxidative enzyme activity, and capillarity. Training results were compared with a sedentary, age- and diagnosis-matched control group (n=10). Peak aerobic capacity increased in the intervention group at 3 months and at 1 year by 16% and 20%, respectively (both P P P Conclusions Older coronary patients successfully improve peak aerobic capacity after 3 and 12 months of supervised aerobic conditioning compared with control subjects. The mechanism of the increase in peak aerobic capacity is associated almost exclusively with peripheral skeletal muscle adaptations, with no discernible improvements in cardiac output or calf blood flow. |
| Databáze: | OpenAIRE |
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