Human leukocyte antigen–A, –B, and –DRB1 allele and haplotype frequencies in the Mozambican population: A blood donor–based population study
| Autor: | António A.A. Assane, Gustavo Milson Fabricio-Silva, Nédio Mabunda, Orlando C. Ferreira, Amina M. Sousa, Juliana Cardoso-Oliveira, Ilesh V. Jani, Luís Cristóvão Porto |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Adolescent Population Immunology Blood Donors Single-nucleotide polymorphism Human leukocyte antigen Biology Gene Frequency Genotype Humans Immunology and Allergy Allele education Allele frequency Mozambique Genetics education.field_of_study HLA-A Antigens Histocompatibility Testing Haplotype HLA-DR Antigens General Medicine Middle Aged Haplotypes HLA-B Antigens Population study Female HLA-DRB1 Chains |
| Zdroj: | Human Immunology. 71:1027-1032 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2010.06.017 |
| Popis: | Human leukocyte antigen (HLA) has been used for several decades as genetic markers for analyzing diversity of gene pool origin, platelet transfusion, tissue transplantation, disease susceptibility or resistance, and forensic and anthropological studies. In the present study, the allele and haplotype frequencies of HLA-A, -B, and -DRB1 were studied in 250 unrelated Mozambican individuals (black African from south of Mozambique Basin) by using a low-medium resolution polymerase chain reaction-Luminex typing method. A total of 18 A, 25 B, and 13 DRB1 alleles were identified. The most frequent HLA-A, -B, and -DRB1 alleles were HLA-A*30 (23.9%), HLA-B*15 (15.6%), and HLA-DRB1*13 (19.8%), respectively. The most frequent two-locus haplotypes were HLA-A*30-B*42 (7.4%) and HLA-B*42-DRB1*03 (5.4%), and three-locus haplotypes were HLA-A*30-B*42-DRB1*03 (4.9%), and HLA-A*02-B*58-DRB1*11 (4.1%). Allele distribution and haplotype analysis demonstrated that Mozambican population shares HLA patterns with sub-Saharan populations. |
| Databáze: | OpenAIRE |
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