Epigenetic factors involved in the pathophysiology of inflammatory skin diseases
| Autor: | Lena Möbus, Hila Emmert, Stephan Weidinger |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Immunology Genome-wide association study Bioinformatics Dermatitis Atopic Epigenesis Genetic 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine Psoriasis Lupus Erythematosus Cutaneous Animals Humans Immunology and Allergy Medicine Epigenetics Skin Inflammation Lupus erythematosus integumentary system business.industry Atopic dermatitis DNA Methylation medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Oral lichen planus business Lichen Planus Oral Filaggrin |
| Zdroj: | Journal of Allergy and Clinical Immunology. 145:1049-1060 |
| ISSN: | 0091-6749 |
| Popis: | Epigenetics has been discussed as a potential factor influencing the pathophysiology and severity of inflammatory skin diseases. In recent years, emerging evidence suggests that epigenetic mechanisms are involved in the pathophysiology of not only atopic dermatitis (AD) and psoriasis (PSO) but also lupus erythematosus and oral lichen. A systematic review of the literature was undertaken to provide an unbiased and comprehensive update on the involvement of methylation patterns in inflammatory skin disease. In addition to reviewing the contribution of epigenetic mechanisms regulating the development of inflammatory skin diseases, this review aimed to discern the overlap of epigenetic risk factors of the 2 most common inflammatory skin diseases, AD and PSO. Although AD and PSO are both inflammatory skin diseases, both show a distinct genetic profile. Herein, we give evidence that both AD and PSO share epigenetic risk factors that might contribute to disease characteristics. We identify a core subset of inflammation-associated differentially methylated genes in both AD and PSO and discuss the association in other inflammatory diseases. |
| Databáze: | OpenAIRE |
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