Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics
| Autor: | Hongchuan Jin, Liyuan Zhu, Shilong Ying, Ya-Dan Li, Xian Wang, Rongkai Shi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Messenger RNA Adenosine lcsh:Cytology Upstream and downstream (transduction) Immunology RNA-Binding Proteins RNA Nerve Tissue Proteins Review Article Cell Biology Computational biology Biology Epigenesis Genetic Domain (software engineering) Cellular and Molecular Neuroscience Neoplasms Animals Humans Epigenetics lcsh:QH573-671 Cancer |
| Zdroj: | Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021) Cell Death & Disease |
| ISSN: | 2041-4889 |
| Popis: | N6-methyladenosine (m6A), the most prevalent and reversible modification of mRNA in mammalian cells, has recently been extensively studied in epigenetic regulation. YTH family proteins, whose YTH domain can recognize and bind m6A-containing RNA, are the main “readers” of m6A modification. YTH family proteins perform different functions to determine the metabolic fate of m6A-modified RNA. The crystal structure of the YTH domain has been completely resolved, highlighting the important roles of several conserved residues of the YTH domain in the specific recognition of m6A-modified RNAs. Upstream and downstream targets have been successively revealed in different cancer types and the role of YTH family proteins has been emphasized in m6A research. This review describes the regulation of RNAs by YTH family proteins, the structural features of the YTH domain, and the connections of YTH family proteins with human cancers. |
| Databáze: | OpenAIRE |
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