Renal biopsy in a patient with haemophilia A and cryoglobulinaemic membranoproliferative glomerulonephritis associated with hepatitis C virus infection

Autor: Ayako Nishihira, Kaname Hirowatari, Eiji Ishimura, Takao Tsuchida, Hideaki Shima, Yoshiki Nishizawa, Kenichi Wakasa, Masaaki Inaba, Katsuhito Mori, Ikue Kobayashi, Kaori Shidara
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Zdroj: NDT Plus
ISSN: 1753-0792
1753-0784
Popis: A renal biopsy was performed in a 47-year-old man with haemophilia A. Thirty minutes after administration of an intravenous bolus of 4000 units of recombinant factor VIII, which increased the activity to 74–91%, a needle renal biopsy was successfully performed, followed by administration of 3000 units of factor VIII in the evening, and then the subsequent morning and evening. The patient was diagnosed with hepatitis C virus-associated membranoproliferative glomerulonephritis. Treatment with interferon, ribavirin, prednisolone and cyclosporine A improved the nephrotic syndrome. This is the first report of a successful renal biopsy in a patient with haemophilia A after factor VIII injection.
Databáze: OpenAIRE