FosL1 Regulates Regional Metastasis of Head and Neck Squamous Cell Carcinoma by Promoting Cell Migration, Invasion, and Proliferation
| Autor: | Hideaki Takahashi, Shoko Shimada, Yoshihiro Aizawa, Nobuhiko Oridate, Kaname Sato, Kentaro Takada, Hiroshi Hyakusoku, Kae Sawakuma, Tatsu Kuwahara, Yasuhiro Isono, Takashi Hatano, Daisuke Sano |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Small interfering RNA Down-Regulation Mice Nude Metastasis Small hairpin RNA Mice Cell Movement In vivo Cell Line Tumor Animals Humans Medicine Neoplasm Invasiveness RNA Small Interfering Cell Proliferation Gene knockdown Squamous Cell Carcinoma of Head and Neck business.industry Cell migration General Medicine FOSL1 Prognosis medicine.disease Head and neck squamous-cell carcinoma stomatognathic diseases Oncology Lymphatic Metastasis Cancer research business Proto-Oncogene Proteins c-fos |
| Zdroj: | Anticancer Research. 41:3317-3326 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background/aim We evaluated the impact of FosL1, a member of the activated protein-1 family, on the pathways leading to regional metastasis of head and neck squamous cell carcinoma (HNSCC). Materials and methods We examined the influence of small interfering RNA (siRNA) and short heparin RNA (shRNA) mediated knockdown of FosL1 on cell migration, invasion, and proliferation in vitro as well as on regional metastasis in vivo. The prognostic significance of FosL1 was also analyzed using the Kaplan- Meier plotter using data from an HNSCC patient database. Results Down-regulation of FosL1 inhibited cell migration, invasion, and proliferation in vitro, decreased the incidence of regional metastases, and prolonged the survival of mice in vivo. We also determined that HNSCC patients with higher expression levels of FosL1 had a significantly shorter survival time than those with low expression of FosL1. Conclusion FosL1 plays a crucial role in promoting cell migration, invasion, and proliferation in HNSCC. |
| Databáze: | OpenAIRE |
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